AIMC Topic: Machine Learning

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A machine-learning-powered spectral-dominant multimodal soft wearable system for long-term and early-stage diagnosis of plant stresses.

Science advances
Addressing the global malnutrition crisis requires precise and timely diagnostics of plant stresses to enhance the quality and yield of nutrient-rich crops, such as tomatoes. Soft wearable sensors offer a promising approach by continuously monitoring...

Neurons throughout the brain embed robust signatures of their anatomical location into spike trains.

eLife
Neurons in the brain are known to encode diverse information through their spiking activity, primarily reflecting external stimuli and internal states. However, whether individual neurons also embed information about their own anatomical location wit...

Machine learning-based comparison of transperineal vs. transrectal biopsy for prostate cancer diagnosis: evaluating procedural effectiveness.

The Canadian journal of urology
BACKGROUND: Transrectal (TR) and transperineal (TP) biopsies are commonly used methods for diagnosing prostate cancer. However, their comparative effectiveness in conjunction with machine learning (ML) techniques remains underexplored. This study aim...

Machine learning for the prediction of spontaneous preterm birth using early second and third trimester maternal blood gene expression: A cautionary tale.

PloS one
Spontaneous preterm birth (sPTB) remains a significant global health challenge and a leading cause of neonatal mortality and morbidity. Despite advancements in neonatal care, the prediction of sPTB remains elusive, in part due to complex etiologies a...

Machine learning application to predict binding affinity between peptide containing non-canonical amino acids and HLA-A0201.

PloS one
Class Ι major histocompatibility complexes (MHC-Ι), encoded by the highly polymorphic HLA-A, HLA-B, and HLA-C genes in humans, are expressed on all nucleated cells. Both self and foreign proteins are processed to peptides of 8-10 amino acids, loaded ...

Comparison of machine learning and validation methods for high-dimensional accelerometer data to detect foot lesions in dairy cattle.

PloS one
Lameness is one of the major production diseases affecting dairy cattle. It is associated with negative welfare in affected cattle, economic losses at the farm level, and adverse effects on sustainability. Prompt identification of lameness is necessa...

3Mont: A multi-omics integrative tool for breast cancer subtype stratification.

PloS one
Breast Cancer (BRCA) is a heterogeneous disease, and it is one of the most prevalent cancer types among women. Developing effective treatment strategies that address diverse types of BRCA is crucial. Notably, among different BRCA molecular sub-types,...

Scaffold Hopping with Generative Reinforcement Learning.

Journal of chemical information and modeling
Scaffold hopping-the design of novel scaffolds for existing lead candidates-is a multifaceted and nontrivial task, for medicinal chemists and computational approaches alike. Generative reinforcement learning can iteratively optimize desirable propert...

AffiGrapher: Contrastive Heterogeneous Graph Learning with Aromatic Virtual Nodes for RNA-Small Molecule Binding Affinity Prediction.

Journal of chemical information and modeling
RNA molecules exhibit diverse structures and functions, making them promising drug targets. However, predicting RNA-small molecule binding affinity remains challenging due to limited experimental data and the structural variability introduced by mult...

Developing interpretable machine learning models to predict length of stay and disposition decision for adult patients in emergency departments.

BMJ health & care informatics
OBJECTIVE: Machine learning (ML) models have emerged as tools to predict length of stay (LOS) and disposition decision (DD) in emergency departments (EDs) to combat overcrowding. However, site-specific ML models are not transferable to different site...