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Comprehensive multi-omics analysis reveals the core role of glycerophospholipid metabolism in the influence of short-chain fatty acids on the development of sepsis.

Scientific reports
Sepsis is a systemic inflammatory response syndrome caused by infection, which has a high morbidity and mortality. Short-chain fatty acids (SCFAs) have been proved to improve the outcome of sepsis by regulating immunity and metabolism, but its specif...

Serum peptide biomarkers by MALDI-TOF MS coupled with machine learning for diagnosis and classification of hepato-pancreato-biliary cancers.

Scientific reports
This study aimed to investigate the potential of peptide mass fingerprints (PMFs) of the serum peptidome using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), in combination with machine learning algorithm...

Exploring the feasibility of AI-based analysis of histopathological variability in salivary gland tumours.

Scientific reports
This study uses artificial intelligence (AI) for differentiation between salivary gland tumours (SGT) using digitised Haematoxylin and Eosin stained whole-slide images (WSI). Machine learning (ML) classifiers were developed and tested using 320 scann...

Application of causal forest double machine learning (DML) approach to assess tuberculosis preventive therapy's impact on ART adherence.

Scientific reports
Adherence to antiretroviral therapy (ART) is critical for HIV treatment success, yet the impact of tuberculosis preventive therapy (TPT) remains inadequately understood. Using observational data from 4152 HIV patients in Ethiopia (2005-2024), we appl...

Enhancing schizophrenia diagnosis efficiency with EEGNet: a simplified recognition model based on γ band features.

Psychiatry research. Neuroimaging
OBJECTIVE: This study aims to develop an objective and efficient diagnostic model for schizophrenia (SCZ) by integrating electroencephalogram (EEG) signals with deep learning techniques. Building on previous research, γ wave activity is selected as a...

Development and validation of interpretable machine learning models for predicting AKI risk in patients treated with PD-1/PD-L1: a retrospective study.

BMC medical informatics and decision making
BACKGROUND: Anti-programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) immunotherapy has revolutionized cancer treatment. However, it can cause immune-related adverse events, including acute kidney injury (AKI). Such adverse e...

Predicting COVID-19 severity in pediatric patients using machine learning: a comparative analysis of algorithms and ensemble methods.

Scientific reports
COVID-19 has posed a significant global health challenge, affecting individuals across all age groups. While extensive research has focused on adults, pediatric patients exhibit distinct clinical characteristics that necessitate specialized predictiv...

Machine learning based analysis of leucocyte cell population data by Sysmex XN series hematology analyzer for the diagnosis of bacteremia.

Scientific reports
In clinical practice, early recognition of bacteremia leads to prognostic improvement. Recently, cell population data (CPD) from the Sysmex XN-series hematology analyzer has attracted attention as a new method for the early diagnosis of bacteremia, b...

Exposotypes in psychotic disorders.

Scientific reports
Psychiatry lags in adopting etiological approaches to diagnosis, prognosis, and outcome prediction compared to the rest of medicine. Etiological factors such as childhood trauma (CHT), substance use (SU), and socioeconomic status (SES) significantly ...

Multimodal Alzheimer's disease recognition from image, text and audio.

Scientific reports
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that significantly affects cognitive function. One widely used diagnostic approach involves analyzing patients' verbal descriptions of pictures. While prior studies have primarily f...