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Unbiased estimation of biomarker panel performance when combining training and testing data in a group sequential design.

Biometrics
Motivated by an ongoing study to develop a screening test able to identify patients with undiagnosed Sjögren's Syndrome in a symptomatic population, we propose methodology to combine multiple biomarkers and evaluate their performance in a two-stage g...

Robots Learn to Recognize Individuals from Imitative Encounters with People and Avatars.

Scientific reports
Prior to language, human infants are prolific imitators. Developmental science grounds infant imitation in the neural coding of actions, and highlights the use of imitation for learning from and about people. Here, we used computational modeling and ...

Rapid identification of slow healing wounds.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Chronic nonhealing wounds have a prevalence of 2% in the United States, and cost an estimated $50 billion annually. Accurate stratification of wounds for risk of slow healing may help guide treatment and referral decisions. We have applied modern mac...

Multivoxel Object Representations in Adult Human Visual Cortex Are Flexible: An Associative Learning Study.

Journal of cognitive neuroscience
Learning associations between co-occurring events enables us to extract structure from our environment. Medial-temporal lobe structures are critical for associative learning. However, the role of the ventral visual pathway (VVP) in associative learni...

A Q-backpropagated time delay neural network for diagnosing severity of gait disturbances in Parkinson's disease.

Journal of biomedical informatics
Parkinson's disease (PD) is a movement disorder that affects the patient's nervous system and health-care applications mostly uses wearable sensors to collect these data. Since these sensors generate time stamped data, analyzing gait disturbances in ...

Predicting Renal Failure Progression in Chronic Kidney Disease Using Integrated Intelligent Fuzzy Expert System.

Computational and mathematical methods in medicine
BACKGROUND: Chronic kidney disease (CKD) is a covert disease. Accurate prediction of CKD progression over time is necessary for reducing its costs and mortality rates. The present study proposes an adaptive neurofuzzy inference system (ANFIS) for pre...

Multivariate pattern classification of pediatric Tourette syndrome using functional connectivity MRI.

Developmental science
Tourette syndrome (TS) is a developmental neuropsychiatric disorder characterized by motor and vocal tics. Individuals with TS would benefit greatly from advances in prediction of symptom timecourse and treatment effectiveness. As a first step, we ap...

Pyeloplasty in children: perioperative results and long-term outcomes of robotic-assisted laparoscopic surgery compared to open surgery.

Pediatric surgery international
BACKGROUND: A few studies have compared robotic-assisted laparoscopic pyeloplasty (RALP) with open pyeloplasty (OP) in children, but no previous study includes a long-term follow-up of renal function and hydronephrosis in combination with a thorough ...

Totally robotic rectal resection: an experience of the first 100 consecutive cases.

International journal of colorectal disease
INTRODUCTION: Robotic surgery provides an alternative option for a minimal access approach. It provides a stable platform with high definition three-dimensional views and improved access, which enhances the capabilities for precise dissection in a na...