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Analysis of the relationships between interferon-stimulated genes and anti-SSA/Ro 60 antibodies in primary Sjögren's syndrome patients via multiomics and machine learning methods.

International immunopharmacology
BACKGROUND: Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease characterized by lymphocyte infiltration of the exocrine glands. Interferon-stimulated genes (ISGs) are often upregulated in patients with pSS, and anti-SSA/Ro 60 a...

Urine Analysed by FTIR, Chemometrics and Machine Learning Methods in Determination Spectroscopy Marker of Prostate Cancer in Urine.

Journal of biophotonics
Prostate-specific antigen (PSA) is the most commonly used marker of prostate cancer. However, nearly 25% of men with elevated PSA levels do not have cancer and nearly 20% of patients with prostate cancer have normal serum PSA levels. Therefore, in th...

Evolution of Linguistic Markers of Agency, Centrality and Content During Metacognitive Therapy for Psychosis: A Pilot Exploratory Study.

Early intervention in psychiatry
AIM: Metacognitive Reflection and Insight Therapy (MERIT) is a form of person-centred psychotherapy that promotes recovery-oriented outcomes by targeting metacognitive capacity. Previous research has shown the feasibility and clinical benefits of MER...

Exploring sensory alterations and repetitive behaviors in children with autism spectrum disorder from the perspective of artificial neural networks.

Research in developmental disabilities
BACKGROUND: Restrictive repetitive behaviors (RRBs) and sensory processing disorders are core symptoms of autism spectrum disorder (ASD). Their relationship is reported, but existing data are conflicting as to whether they are related but distinct, o...

Learning a Hand Model From Dynamic Movements Using High-Density EMG and Convolutional Neural Networks.

IEEE transactions on bio-medical engineering
OBJECTIVE: Surface electromyography (sEMG) can sense the motor commands transmitted to the muscles. This work presents a deep learning method that can decode the electrophysiological activity of the forearm muscles into the movements of the human han...

A Deep Dynamic Causal Learning Model to Study Changes in Dynamic Effective Connectivity During Brain Development.

IEEE transactions on bio-medical engineering
OBJECTIVE: Brain dynamic effective connectivity (dEC), characterizes the information transmission patterns between brain regions that change over time, which provides insight into the biological mechanism underlying brain development. However, most e...

Learning Motion Primitives for the Quantification and Diagnosis of Mobility Deficits.

IEEE transactions on bio-medical engineering
The severity of mobility deficits is one of the most critical parameters in the diagnosis of Parkinson's disease (PD) and rehabilitation. The current approach for severity evaluation is clinical scaling that relies on a clinician's subjective observa...

Leveraging Bioinformatics and Machine Learning for Identifying Prognostic Biomarkers and Predicting Clinical Outcomes in Lung Adenocarcinoma.

Genes
There exist significant challenges for lung adenocarcinoma (LUAD) due to its poor prognosis and limited treatment options, particularly in the advanced stages. It is crucial to identify genetic biomarkers for improving outcome predictions and guidin...