AIMC Topic: Metabolomics

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Defining lipedema's molecular hallmarks by multi-omics approach for disease prediction in women.

Metabolism: clinical and experimental
Lipedema is a chronic disease in females characterized by pathologic subcutaneous adipose tissue expansion and hitherto remains without druggable targets. In this observational study, we investigated the molecular hallmarks of lipedema using an unbia...

Foodomics approaches: New insights in phenolic compounds analysis.

Food research international (Ottawa, Ont.)
Fruits, vegetables, and plant-based foods contain several bioactive substances such as phenolic compounds (PCs), that are plant secondary metabolites with attributed health properties. The study of the metabolic pathways of PCs, including those relat...

Machine learning-derived diagnostic model of epithelial ovarian cancer based on gut microbiome signatures.

Journal of translational medicine
BACKGROUND: Prior studies have elucidated that alterations in gut microbiota are associated with a spectrum of tumors and metabolic disorders. However, the diagnostic value of gut microbiota in epithelial ovarian cancer remains insufficiently investi...

Metabolomics and machine learning approaches for diagnostic biomarkers screening in systemic light chain amyloidosis.

Annals of hematology
Delayed diagnosis of systemic light chain (AL) amyloidosis is common and associated with worse survival and early mortality. Current diagnosis still relies on invasive tissue biopsies, highlighting the need for sensitive, noninvasive biomarkers for e...

The dawn of the revolution that will allow us to precisely describe how microbiomes function.

Journal of proteomics
The community of microorganisms inhabiting a specific environment, such as the human gut - including bacteria, fungi, archaea, viruses, protozoa, and others - is known as the microbiota. A holobiont, in turn, refers to an integrated ecological unit w...

Development of disease diagnosis technology based on coattention cross-fusion of multiomics data.

Analytica chimica acta
BACKGROUND: Early diagnosis is vital for increasing the rates of curing diseases and patient survival in medicine. With the advancement of biotechnology, the types of bioomics data are increasing. The integration of multiomics data can provide more c...

FIORA: Local neighborhood-based prediction of compound mass spectra from single fragmentation events.

Nature communications
Non-targeted metabolomics holds great promise for advancing precision medicine and biomarker discovery. However, identifying compounds from tandem mass spectra remains a challenging task due to the incomplete nature of spectral reference libraries. A...

Bootstrap inference and machine learning reveal core differential plasma metabolic connectome signatures in major depressive disorder.

Journal of affective disorders
BACKGROUND: Major depressive disorder (MDD) involves molecular alterations and pathway dysregulation. Metabolic interconnections are crucial for normal functioning, yet current analysis focuses on individual pathways or biomarkers, overlooking intric...

Machine Learning-Based Identification of Novel Exosome-Derived Metabolic Biomarkers for the Diagnosis of Systemic Lupus Erythematosus and Differentiation of Renal Involvement.

Current medical science
OBJECTIVE: This study aims to investigate the exosome-derived metabolomicsĀ profiles in systemic lupus erythematosus (SLE), identify differential metabolites, and analyze their potential as diagnostic markers for SLE and lupus nephritis (LN).

Multilayered visual metabolomics analysis framework for enhanced exploration of functional components in wolfberry.

Food chemistry
Wolfberry, regarded as a nutritious fruit, has garnered significant attention in the food industry due to potential health benefits. However, the tissue-specific distribution and dynamic accumulation patterns of nutritional metabolites such as flavon...