AIMC Topic: Mice, Inbred C57BL

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Bursts with High and Low Load of Epileptiform Spikes Show Context-Dependent Correlations in Epileptic Mice.

eNeuro Sep 5, 2019
Hypersynchronous network activity is the defining hallmark of epilepsy and manifests in a wide spectrum of phenomena, of which electrographic activity during seizures is only one extreme. The aim of this study was to differentiate between different t...
Machine Learning Animals Electroencephalography Epilepsy Hippocampus Kainic Acid Male Mice Action Potentials Mice, Inbred C57BL
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Robotic platform for microinjection into single cells in brain tissue.

EMBO reports Aug 30, 2019
Microinjection into single cells in brain tissue is a powerful technique to study and manipulate neural stem cells. However, such microinjection requires expertise and is a low-throughput process. We developed the "Autoinjector", a robot that utilize...
Humans Brain Animals Single-Cell Analysis Robotics Cell Communication Neurogenesis Automation Image Processing, Computer-Assisted Microinjections RNA, Messenger Cell Lineage Neural Stem Cells Mice, Inbred C57BL Telencephalon
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Deep Learning Diffuse Optical Tomography.

IEEE transactions on medical imaging Aug 20, 2019
Diffuse optical tomography (DOT) has been investigated as an alternative imaging modality for breast cancer detection thanks to its excellent contrast to hemoglobin oxidization level. However, due to the complicated non-linear photon scattering physi...
Phantoms, Imaging Tomography, Optical Image Processing, Computer-Assisted Mice Mice, Inbred C57BL Neoplasms, Experimental Algorithms Animals Deep Learning Cell Line, Tumor
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Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis.

Nature neuroscience Jul 25, 2019
Studies of patients afflicted by neurodegenerative diseases suggest that misfolded proteins spread through the brain along anatomically connected networks, prompting progressive decline. Recently, mouse models have recapitulated the cell-to-cell tran...
Mice, Inbred C57BL Brain Mapping alpha-Synuclein Neurons Male Mice Models, Neurological Cell Death Linear Models Connectome Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Neural Networks, Computer Brain Female Animals
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Instant White Rice with Pigmented Giant Embryonic Rice Improves Glucose Metabolism and Inhibits Oxidative Stress in High-Fat Diet-Fed Mice.

International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition May 24, 2019
The effects of instant cooked rice made from a combination of white rice and pigmented giant embryonic Keunnunjami rice, in comparison with those of instant regular white or brown rice and instant non-pigmented giant embryonic brown rice, on the gluc...
Liver Oxidative Stress Animals Diet, High-Fat Mice Oryza Antioxidants Male Random Allocation Mice, Inbred C57BL Blood Glucose
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Multi-Dimensional Mapping of Brain-Derived Extracellular Vesicle MicroRNA Biomarker for Traumatic Brain Injury Diagnostics.

Journal of neurotrauma May 6, 2019
The diagnosis and prognosis of traumatic brain injury (TBI) is complicated by variability in the type and severity of injuries and the multiple endophenotypes that describe each patient's response and recovery to the injury. It has been challenging t...
Brain Injuries, Traumatic Mice, Inbred C57BL MicroRNAs Receptors, AMPA Animals Male Extracellular Vesicles Mice Humans Machine Learning Biomarkers
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Refining humane endpoints in mouse models of disease by systematic review and machine learning-based endpoint definition.

ALTEX Apr 18, 2019
Ideally, humane endpoints allow for early termination of experiments by minimizing an animal's discomfort, distress and pain, while ensuring that scientific objectives are reached. Yet, lack of commonly agreed methodology and heterogeneity of cut-off...
Disease Models, Animal Mice, Inbred C57BL Mice, Knockout Systematic Reviews as Topic Random Allocation Female Sepsis Stroke Animals Body Temperature Body Weight Time Factors Male Ethical Review Supervised Machine Learning Mice Severity of Illness Index Animal Welfare
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PatcherBot: a single-cell electrophysiology robot for adherent cells and brain slices.

Journal of neural engineering Apr 10, 2019
OBJECTIVE: Intracellular patch-clamp electrophysiology, one of the most ubiquitous, high-fidelity techniques in biophysics, remains laborious and low-throughput. While previous efforts have succeeded at automating some steps of the technique, here we...
Humans Cells, Cultured Brain Animals Male Mice Mice, Inbred C57BL Electrophysiological Phenomena Robotics Patch-Clamp Techniques HEK293 Cells Organ Culture Techniques
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Autonomous patch-clamp robot for functional characterization of neurons in vivo: development and application to mouse visual cortex.

Journal of neurophysiology Apr 10, 2019
Patch clamping is the gold standard measurement technique for cell-type characterization in vivo, but it has low throughput, is difficult to scale, and requires highly skilled operation. We developed an autonomous robot that can acquire multiple cons...
Mice Mice, Inbred C57BL Robotics Neurons Photic Stimulation Visual Cortex Electrophysiological Phenomena Patch-Clamp Techniques Animals Male
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Characterisation of nonlinear receptive fields of visual neurons by convolutional neural network.

Scientific reports Mar 7, 2019
A comprehensive understanding of the stimulus-response properties of individual neurons is necessary to crack the neural code of sensory cortices. However, a barrier to achieving this goal is the difficulty of analysing the nonlinearity of neuronal r...
Sensory Receptor Cells Neural Networks, Computer Mice, Inbred C57BL Nonlinear Dynamics Photic Stimulation Animals Visual Cortex Male Models, Neurological
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