AIMC Topic: Mice

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PsyGeNET: a knowledge platform on psychiatric disorders and their genes.

Bioinformatics (Oxford, England)
UNLABELLED: PsyGeNET (Psychiatric disorders and Genes association NETwork) is a knowledge platform for the exploratory analysis of psychiatric diseases and their associated genes. PsyGeNET is composed of a database and a web interface supporting data...

Deep convolutional neural networks for annotating gene expression patterns in the mouse brain.

BMC bioinformatics
BACKGROUND: Profiling gene expression in brain structures at various spatial and temporal scales is essential to understanding how genes regulate the development of brain structures. The Allen Developing Mouse Brain Atlas provides high-resolution 3-D...

Toll-like receptor signaling in vertebrates: testing the integration of protein, complex, and pathway data in the protein ontology framework.

PloS one
The Protein Ontology (PRO) provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes. Comprehensive curation o...

Ontology application and use at the ENCODE DCC.

Database : the journal of biological databases and curation
The Encyclopedia of DNA elements (ENCODE) project is an ongoing collaborative effort to create a catalog of genomic annotations. To date, the project has generated over 4000 experiments across more than 350 cell lines and tissues using a wide array o...

A nanoparticulate drug-delivery system for glaucocalyxin A: formulation, characterization, increased in vitro, and vivo antitumor activity.

Drug delivery
Glaucocalyxin A (GLA) is a phytochemical component with multiple pharmacological activities; however, glaucocalyxin A's wider use has been restricted by its poor solubility. In this study, GLA nanosuspensions were prepared with precipitation-combined...

Computationally predicting protein-RNA interactions using only positive and unlabeled examples.

Journal of bioinformatics and computational biology
Protein-RNA interactions (PRIs) are considerably important in a wide variety of cellular processes, ranging from transcriptional and post-transcriptional regulations of gene expression to the active defense of host against virus. With the development...

Modeling analgesic drug interactions using support vector regression: a new approach to isobolographic analysis.

Journal of pharmacological and toxicological methods
BACKGROUND: Modeling drug interactions is important for illustrating combined drug actions and for predicting the pharmacological and/or toxicological effects that can be obtained using combined drug therapy.

Robotic adherent cell injection for characterizing cell-cell communication.

IEEE transactions on bio-medical engineering
Compared to robotic injection of suspended cells (e.g., embryos and oocytes), fewer attempts were made to automate the injection of adherent cells (e.g., cancer cells and cardiomyocytes) due to their smaller size, highly irregular morphology, small t...

PoseR: a deep learning toolbox for classifying animal behaviour.

Open biology
The actions of animals provide a window into how their minds work. Recent advances in deep learning are providing powerful approaches to recognize patterns of animal movement from video recordings using markerless pose estimation models. Current meth...