AIMC Topic: Mice

Clear Filters Showing 61 to 70 of 1771 articles

Identification of key diagnostic and prognostic biomarkers for aortic valve stenosis with coronary artery disease through immunological profiling integrating proteomics, single-cell sequencing, and machine learning.

Biochemical and biophysical research communications Oct 24, 2025
BACKGROUND: Aortic valve stenosis with coronary artery disease (AS-CAD) represents a common yet complex cardiovascular comorbidity, characterized by multifactorial pathogenesis and a lack of specific serum biomarkers. These limitations hinder early d...
Male Single-Cell Analysis Protein Interaction Maps Mice Female Aged Animals Fibrinogen Proteomics Aortic Valve Stenosis Coronary Artery Disease Humans Machine Learning Biomarkers Prognosis
View on PubMed DOI

Whole-genome sequencing reveals individual and cohort level insights into chromosome 9p syndromes.

Genome medicine Oct 24, 2025
BACKGROUND: Previous genomic efforts on chromosome 9p deletion and duplication syndromes have utilized low-resolution strategies (i.e., karyotypes, chromosome microarrays). These studies have provided important initial insights into these syndromes. ...
Chromosome Disorders Chromosomes, Human, Pair 9 Male Humans DNA Copy Number Variations Female Cohort Studies Syndrome Animals Mice Whole Genome Sequencing Chromosome Deletion
View on PubMed DOI

Real-time self-supervised denoising for high-speed fluorescence neural imaging.

Nature communications Oct 24, 2025
Self-supervised denoising methods significantly enhance the signal-to-noise ratio in fluorescence neural imaging, yet real-time solutions remain scarce in high-speed applications. Here, we present the FrAme-multiplexed SpatioTemporal learning strateg...
Neurons Signal-To-Noise Ratio Optical Imaging Animals Deep Learning Image Processing, Computer-Assisted Mice Neural Networks, Computer
View on PubMed DOI

Integrated experimental, computational and machine learning approaches for the development of Apremilast-Aceclofenac coamorphous systems.

International journal of pharmaceutics Oct 23, 2025
Understanding the molecular mechanisms of drug coamorphization remains a key challenge in solid-state pharmaceutics. This study presents a molecular level strategy for designing drug-drug coamorphous systems (CAMs) of apremilast (APR) and aceclofenac...
Animals Mice Thalidomide Anti-Inflammatory Agents, Non-Steroidal Machine Learning Cytokines RAW 264.7 Cells Calorimetry, Differential Scanning X-Ray Diffraction Diclofenac Molecular Dynamics Simulation Solubility Drug Liberation
View on PubMed DOI

A multistep platform identifies spleen-tropic lipid nanoparticles for in vivo T cell-targeted delivery of gene-editing proteins.

Science advances Oct 22, 2025
Lipid nanoparticles (LNPs) are a promising nonviral delivery system for gene-editing proteins, but optimal formulations remain underexplored. Unlike messenger RNA-based approaches, ribonucleoprotein delivery enables immediate genome editing without r...
Animals T-Lymphocytes Mice Nanoparticles Lipids CRISPR-Cas Systems Liposomes Humans Receptors, CCR5 Gene Editing Spleen Gene Transfer Techniques
View on PubMed DOI

Establishment of an Infrared-Camera-Based Home-Cage Tracking System Goblotrop.

eNeuro Oct 22, 2025
Studying locomotor activity in animal models is crucial for understanding physiological, behavioral, and pathological processes. This study aimed to develop an artificial intelligence-based tracking system called Goblotrop, designed to localize roden...
Video Recording Behavior, Animal Infrared Rays Neural Networks, Computer Motor Activity Artificial Intelligence Anorexia Nervosa Female Starvation Animals Mice Disease Models, Animal Mice, Inbred C57BL
View on PubMed DOI

Machine learning and multi-omics integration reveal TRPV2 as a central regulator in bicuspid aortic valve calcification.

Biochemical and biophysical research communications Oct 21, 2025
BACKGROUND: Bicuspid aortic valve (BAV), the most common congenital heart defect, is strongly predisposed to early calcification, yet the molecular drivers remain poorly defined. This study aims to identify the functional role of transient receptor p...
Humans Machine Learning Animals Aortic Valve Disease Aortic Valve MicroRNAs RNA, Long Noncoding Osteogenesis Bicuspid Aortic Valve Disease Heart Valve Diseases Mice Calcium Channels Multiomics Calcinosis Aortic Valve Stenosis Gene Expression Profiling TRPV Cation Channels Gene Regulatory Networks
View on PubMed DOI

Descattering and image restoration with a transformer-based neural network in deep tissue imaging.

Proceedings of the National Academy of Sciences of the United States of America Oct 21, 2025
Imaging biological structures deep inside tissues is crucial but challenging due to common light scattering. This study proposes a multiattention network that directly maps degraded scattering two-photon excitation fluorescence (TPEF) images to high-...
Mice Signal-To-Noise Ratio Lipid Droplets Brain Animals Image Processing, Computer-Assisted Neural Networks, Computer
View on PubMed DOI

Cell Decoder: decoding cell identity with multi-scale explainable deep learning.

Genome biology Oct 20, 2025
BACKGROUND: Cells are the fundamental units of life, and understanding their diversity and functionality requires detailed characterization. The rise of single-cell omics data enables this, yet current deep learning approaches lack multi-scale interp...
Deep Learning Single-Cell Analysis Mice Humans Animals
View on PubMed DOI

A machine learning framework for classifying lipids in untargeted metabolomics using mass-to-charge ratios and retention times.

Metabolomics : Official journal of the Metabolomic Society Oct 18, 2025
INTRODUCTION: The identification of unknown metabolites remains a major challenge in untargeted metabolomics using liquid chromatography-mass spectrometry (LC-MS). This process typically depends on comparing mass spectral or chromatographic data to r...
Mice Humans Metabolomics Machine Learning Chromatography, Liquid Tandem Mass Spectrometry Animals Lipids Lung Neoplasms
View on PubMed DOI
Popular Topics
Recent Journals