AIMC Topic: Mice

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Impact of chronic intermittent hypoxia on the long non-coding RNA and mRNA expression profiles in myocardial infarction.

Journal of cellular and molecular medicine Nov 20, 2020
Chronic intermittent hypoxia (CIH) is the primary feature of obstructive sleep apnoea (OSA), a crucial risk factor for cardiovascular diseases. Long non-coding RNAs (lncRNAs) in myocardial infarction (MI) pathogenesis have drawn considerable attentio...
Gene Ontology Blotting, Western Myocardial Infarction Hypoxia Animals Male Echocardiography Mice RNA, Messenger Disease Models, Animal Mice, Inbred C57BL RNA, Long Noncoding
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Deep learning-enabled multi-organ segmentation in whole-body mouse scans.

Nature communications Nov 6, 2020
Whole-body imaging of mice is a key source of information for research. Organ segmentation is a prerequisite for quantitative analysis but is a tedious and error-prone task if done manually. Here, we present a deep learning solution called AIMOS that...
Spleen X-Ray Microtomography Whole Body Imaging Animal Structures Kidney Mice, Inbred C57BL Liver Reproducibility of Results Animals Male Lung Deep Learning Image Processing, Computer-Assisted Mice Algorithms Brain Female
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Deep Learning-Based Segmentation and Quantification in Experimental Kidney Histopathology.

Journal of the American Society of Nephrology : JASN Nov 5, 2020
BACKGROUND: Nephropathologic analyses provide important outcomes-related data in experiments with the animal models that are essential for understanding kidney disease pathophysiology. Precision medicine increases the demand for quantitative, unbiase...
Male Diagnosis, Computer-Assisted Deep Learning Image Processing, Computer-Assisted Neural Networks, Computer Algorithms Reproducibility of Results Animals Schiff Bases Pattern Recognition, Automated Periodic Acid Mice, Inbred C57BL Kidney Diseases Kidney Glomerulus Mice Translational Research, Biomedical Kidney Disease Models, Animal
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Improving area of occupancy estimates for parapatric species using distribution models and support vector machines.

Ecological applications : a publication of the Ecological Society of America Nov 4, 2020
As geographic range estimates for the IUCN Red List guide conservation actions, accuracy and ecological realism are crucial. IUCN's extent of occurrence (EOO) is the general region including the species' range, while area of occupancy (AOO) is the su...
Mice Support Vector Machine Animals Climate Change Ecosystem Climate
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Learning and interpreting the gene regulatory grammar in a deep learning framework.

PLoS computational biology Nov 2, 2020
Deep neural networks (DNNs) have achieved state-of-the-art performance in identifying gene regulatory sequences, but they have provided limited insight into the biology of regulatory elements due to the difficulty of interpreting the complex features...
Transcription Factors Databases, Genetic Terminology as Topic Binding Sites Mice Neural Networks, Computer Computational Biology Models, Genetic Computer Simulation Enhancer Elements, Genetic Animals Genes, Regulator Deep Learning Gene Regulatory Networks
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m5CPred-SVM: a novel method for predicting m5C sites of RNA.

BMC bioinformatics Oct 30, 2020
BACKGROUND: As one of the most common post-transcriptional modifications (PTCM) in RNA, 5-cytosine-methylation plays important roles in many biological functions such as RNA metabolism and cell fate decision. Through accurate identification of 5-meth...
Mice Support Vector Machine Internet Base Sequence RNA Humans Arabidopsis Animals 5-Methylcytosine ROC Curve
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Deep Learning-Based Spectral Unmixing for Optoacoustic Imaging of Tissue Oxygen Saturation.

IEEE transactions on medical imaging Oct 28, 2020
Label free imaging of oxygenation distribution in tissues is highly desired in numerous biomedical applications, but is still elusive, in particular in sub-epidermal measurements. Eigenspectra multispectral optoacoustic tomography (eMSOT) and its Bay...
Bayes Theorem Animals Oxygen Deep Learning Photoacoustic Techniques Tomography Mice
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A Comprehensive Analysis of MicroRNAs in Human Osteoporosis.

Frontiers in endocrinology Oct 21, 2020
MicroRNAs (miRNAs) are single-stranded RNA molecules that control gene expression in various processes, such as cancers, Alzheimer's disease, and bone metabolic diseases. However, the regulatory roles of miRNAs in osteoporosis have not been systemati...
Mice Disease Models, Animal Humans Male Computational Biology Osteoporosis MicroRNAs Gene Expression Profiling Databases, Genetic Animals Hindlimb Suspension Protein Interaction Maps Gene Ontology Gene Regulatory Networks
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3D convolutional neural networks-based segmentation to acquire quantitative criteria of the nucleus during mouse embryogenesis.

NPJ systems biology and applications Oct 20, 2020
During embryogenesis, cells repeatedly divide and dynamically change their positions in three-dimensional (3D) space. A robust and accurate algorithm to acquire the 3D positions of the cells would help to reveal the mechanisms of embryogenesis. To ac...
Embryo, Mammalian Animals Embryonic Development Imaging, Three-Dimensional Cell Nucleus Neural Networks, Computer Mice Microscopy, Fluorescence
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Deep learning-assisted comparative analysis of animal trajectories with DeepHL.

Nature communications Oct 20, 2020
A comparative analysis of animal behavior (e.g., male vs. female groups) has been widely used to elucidate behavior specific to one group since pre-Darwinian times. However, big data generated by new sensing technologies, e.g., GPS, makes it difficul...
Birds Deep Learning Mice Insecta Behavior, Animal Movement Ursidae Neural Networks, Computer Software Female Animals
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