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Predicting clozapine-induced adverse drug reaction biomarkers using machine learning.
Scientific reports
Jul 15, 2025
Clozapine is an atypical antipsychotic used for patients with treatment-resistant schizophrenia. This drug has serious adverse drug reactions (ADRs), including the risk of severe neutropenia (agranulocytosis). Patients who could benefit from clozapin...
Objective monitoring of motor symptom severity and their progression in Parkinson's disease using a digital gait device.
Scientific reports
Jul 15, 2025
Digital technologies for monitoring motor symptoms of Parkinson's Disease (PD) underwent a strong evolution during the past years. Although it has been shown for several devices that derived digital gait features can reliably discriminate between hea...
Developing a machine-learning model to enable treatment selection for neoadjuvant chemotherapy for esophageal cancer.
Scientific reports
Jul 15, 2025
Although neoadjuvant chemotherapy with docetaxel + cisplatin + 5-fluorouracil (CF) has been the standard treatment for stage II and III esophageal cancers, it is associated with severe adverse events caused by docetaxel. Consequently, this study aime...
Machine learning-enabled estimation of cardiac output from peripheral waveforms is independent of blood pressure measurement location in an in silico population.
Scientific reports
Jul 15, 2025
Monitoring of cardiac output (CO) is a mainstay of hemodynamic management in the acutely or critically ill patient. Invasive determination of CO using thermodilution, albeit regarded as the gold standard, is cumbersome and bears risks inherent to cat...
Preoperative prediction value of 2.5D deep learning model based on contrast-enhanced CT for lymphovascular invasion of gastric cancer.
Scientific reports
Jul 15, 2025
To develop and validate artificial intelligence models based on contrast-enhanced CT(CECT) images of venous phase using deep learning (DL) and Radiomics approaches to predict lymphovascular invasion in gastric cancer prior to surgery. We retrospectiv...
Evaluating cognitive decline detection in aging populations with single-channel EEG features based on two studies and meta-analysis.
Scientific reports
Jul 15, 2025
Timely detection of cognitive decline is paramount for effective intervention, prompting researchers to leverage EEG pattern analysis, focusing particularly on cognitive load, to establish reliable markers for early detection and intervention. This c...
Poincare guided geometric UNet for left atrial epicardial adipose tissue segmentation in Dixon MRI images.
Scientific reports
Jul 15, 2025
Epicardial Adipose Tissue (EAT) is a recognized risk factor for cardiovascular diseases and plays a pivotal role in the pathophysiology of Atrial Fibrillation (AF). Accurate automatic segmentation of the EAT around the Left Atrium (LA) from Magnetic ...
Evaluating the Usability of an HIV Prevention Artificial Intelligence Chatbot in Malaysia: National Observational Study.
JMIR human factors
Jul 15, 2025
BACKGROUND: Malaysia, an upper middle-income country in the Asia-Pacific region, has an HIV epidemic that has transitioned from needle sharing to sexual transmission, mainly in men who have sex with men (MSM). MSM are the most vulnerable population f...
Multimodal Detection of Agitation in People With Dementia in Clinical Settings: Observational Pilot Study.
JMIR aging
Jul 15, 2025
BACKGROUND: Dementia is a progressive neurodegenerative condition that affects millions worldwide, often accompanied by agitation and aggression (AA), which contribute to patient distress and increased health care burden. Existing assessment methods ...
Development and Validation of a Large Language Model-Powered Chatbot for Neurosurgery: Mixed Methods Study on Enhancing Perioperative Patient Education.
Journal of medical Internet research
Jul 15, 2025
BACKGROUND: Perioperative education is crucial for optimizing outcomes in neuroendovascular procedures, where inadequate understanding can heighten patient anxiety and hinder care plan adherence. Current education models, reliant on traditional consu...
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