Cholangiocarcinoma is a very deadly epithelial cell cancer with poor clinical outcome. Cellular senescence plays a vital role in the oncogenesis and the aggressiveness of cholangiocarcinoma. Integrative machine learning procedure including 10 methods...
Gut dysbiosis and systemic inflammation are increasingly recognized in the pathogenesis of knee osteoarthritis (OA). While altered gut microbiota profiles have been reported, the link between specific microbial taxa and physical functioning in OA pat...
Meniere's disease (MD), a degenerative inner ear disorder, is characterized by debilitating episodic vertigo and hearing fluctuations, progressing to permanent sensory impairment. The prevailing dogma attributes these symptoms to abnormal inner ear f...
Due to the widespread COVID-19 vaccinations, we are focusing more on side effects to immunizations that might affect people's perceptions, and ultimately vaccine hesitancy. Machine learning (ML)-based predictive models using individual-level data ser...
OBJECTIVE: This investigation seeks to examine how varying longitudinal patterns in nutritional inflammatory index (NII) correlate with clinical outcomes in cervical cancer patients, while developing predictive models for prognosis.
BACKGROUND: Large Language Models (LLMs) such as ChatGPT and Google Gemini are increasingly explored for their potential in patient education, particularly in the perioperative setting. As text-based tools trained on extensive datasets, they can gene...
BACKGROUND: Parkinson's disease is a movement disorder featuring motor symptoms and cognitive decline, which can manifest as mild cognitive impairment. The incidence of mild cognitive impairment increases with disease progression, and Parkinson's dis...
Sjögren's disease is often an underdiagnosed autoimmune condition that primarily affects the exocrine glands, resulting in symptoms such as dry eyes and dry mouth. Diagnostic challenges stem from nonspecific symptoms, the absence of definitive biomar...
BACKGROUND: HPV status is a key determinant of prognosis and treatment response in head and neck squamous cell carcinoma (HNSCC). To investigate how HPV influences the tumor-immune-stromal landscape, we performed high-dimensional spatial profiling, i...
BMC medical informatics and decision making
Nov 18, 2025
BACKGROUND: Cardiovascular disease (CVD) continues to be a leading cause of disease burden and mortality worldwide. Identifying reliable biomarkers for CVD risk assessment is essential. This study investigates the association between the C-reactive p...
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