AIMC Topic: Middle Aged

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Deep Learning Radiomics Model Based on Computed Tomography Image for Predicting the Classification of Osteoporotic Vertebral Fractures: Algorithm Development and Validation.

JMIR medical informatics
BACKGROUND: Osteoporotic vertebral fractures (OVFs) are common in older adults and often lead to disability if not properly diagnosed and classified. With the increased use of computed tomography (CT) imaging and the development of radiomics and deep...

Mapping Vaccine Sentiment by Analyzing Spanish-Language Social Media Posts and Survey-Based Public Opinion: Dual Methods Study.

JMIR infodemiology
BACKGROUND: The internet and social media have been considered useful platforms for obtaining health information. However, critical and erroneous content about vaccines on social media has been associated with vaccination delays and refusal.

Recognizing Skateboard and Kickboard Commuting Behaviors Using Activity Trackers: Feasibility Study Using Machine Learning Approaches.

JMIR formative research
BACKGROUND: Active commuting, such as skateboarding and kickboarding, is gaining popularity as an alternative to traditional modes of transportation such as walking and cycling. However, current activity trackers and smartphones, which rely on accele...

Integrative analysis of transcriptome and metabolome profiles reveals immune-metabolic alterations in pulmonary sarcoidosis.

Metabolomics : Official journal of the Metabolomic Society
BACKGROUND: Pulmonary sarcoidosis, a disease of unknown etiology, is characterized by the presence of noncaseating granulomas in lung parenchyma. This present study combines metabolomic and transcriptomic data to determine the metabolic and different...

Identifying key brain pathology in bipolar and unipolar depression using a region-specific brain aging trajectories approach: Insights from the Taiwan Aging and Mental Illness Cohort.

Psychological medicine
BACKGROUND: Identifying key areas of brain dysfunction in mental illness is critical for developing precision diagnosis and treatment. This study aimed to develop region-specific brain aging trajectory prediction models using multimodal magnetic reso...

A cross-sectional and bioinformatics-based analysis: perirenal fat thickness as a superior predictor of kidney stone disease.

Lipids in health and disease
BACKGROUND: Kidney stone disease (KSD) is a growing global health concern, with obesity (OB) as a major risk factor linked to metabolic dysfunction and chronic inflammation. Although the common method for evaluating OB is body mass index (BMI), it is...

Predicting one-year post-surgical recurrence in colorectal liver metastasis using CT radiomics and machine learning.

PloS one
BACKGROUND: Early recurrence in colorectal cancer liver metastases (CRLM) typically correlates with significantly worse survival outcomes. There is a strong demand for developing robust and interpretable approaches to assist clinicians in identifying...

Perivascular inflammation in the progression of aortic aneurysms in Marfan syndrome.

JCI insight
Inflammation plays important roles in the pathogenesis of vascular diseases. We here show the involvement of perivascular inflammation in aortic dilatation of Marfan syndrome (MFS). In the aorta of patients with MFS and Fbn1C1041G/+ mice, macrophages...

Inflammation and B cell activation define a plasma proteome signature predicting tuberculosis in people with HIV.

mBio
Improved biomarkers for predicting progression to active tuberculosis (TB) are urgently needed, especially in people with HIV, who are at elevated risk. We used high-throughput plasma proteomics and machine learning to identify signatures associated ...

Nasopharyngeal cancer adaptive radiotherapy with CBCT-derived synthetic CT: deep learning-based auto-segmentation precision and dose calculation consistency on a C-Arm linac.

Radiation oncology (London, England)
BACKGROUND: To evaluate the precision of automated segmentation facilitated by deep learning (DL) and dose calculation in adaptive radiotherapy (ART) for nasopharyngeal cancer (NPC), leveraging synthetic CT (sCT) images derived from cone-beam CT (CBC...