AIMC Topic: Models, Biological

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Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development.

Drug metabolism and disposition: the biological fate of chemicals
It is generally acknowledged that there is a need and role for informative pharmacokinetic models to improve predictions and simulation as well as individualization of drug therapy in pediatric populations of different ages and developmental stages. ...

Applying fuzzy logic to estimate the parameters of the length-weight relationship.

Brazilian journal of biology = Revista brasleira de biologia
We evaluated three mathematical procedures to estimate the parameters of the relationship between weight and length for Cichla monoculus: least squares ordinary regression on log-transformed data, non-linear estimation using raw data and a mix of mul...

Study of human walking patterns based on the parameter optimization of a passive dynamic walking robot.

Technology and health care : official journal of the European Society for Engineering and Medicine
BACKGROUND: The study of human walking patterns mainly focuses on how control affects walking because control schemes are considered to be dominant in human walking.

What is information?

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
Molecular biology is based on two great discoveries: the first is that genes carry hereditary information in the form of linear sequences of nucleotides; the second is that in protein synthesis a sequence of nucleotides is translated into a sequence ...

Body-mounted robotic instrument guide for image-guided cryotherapy of renal cancer.

Medical physics
PURPOSE: Image-guided cryotherapy of renal cancer is an emerging alternative to surgical nephrectomy, particularly for those who cannot sustain the physical burden of surgery. It is well known that the outcome of this therapy depends on the accurate ...

The drug target genes show higher evolutionary conservation than non-target genes.

Oncotarget
Although evidence indicates that drug target genes share some common evolutionary features, there have been few studies analyzing evolutionary features of drug targets from an overall level. Therefore, we conducted an analysis which aimed to investig...

Predictive model of synovial membrane degradation using semi-automated morphometry and artificial neural networks.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
Gonarthrosis is a degenerative disease that affects mainly older people, but whose incidence has increased significantly in the last decade in population under the age of 65. The main objective of this study was developing a predictive model of synov...

Predicting IVF Outcome: A Proposed Web-based System Using Artificial Intelligence.

In vivo (Athens, Greece)
AIM: To propose a functional in vitro fertilization (IVF) prediction model to assist clinicians in tailoring personalized treatment of subfertile couples and improve assisted reproduction outcome.