AIMC Topic: Multiomics

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Integrating deep learning and multi-omics features in radiation pneumonitis prediction for lung cancer patients using PET/CT.

BMC medical imaging
BACKGROUND: To investigate the feasibility and accuracy of PET radiomics features, along with their combination with CT radiomics, dosiomics, and deep learning (DL) features, in predicting radiation pneumonitis (RP) in lung cancer patients treated wi...

Plasma multi-omics and machine learning reveal predictive biomarkers for type 2 diabetes and retinopathy in Qatar biobank cohort.

Journal of translational medicine
BACKGROUND: Type 2 diabetes (T2D) and its vascular complications, including diabetic retinopathy (DR), are escalating in prevalence globally, with disproportionately high prevalence in Middle Eastern populations, where genetic predispositions and lif...

Harnessing multi-omics and genome-editing technologies for climate-resilient agriculture: bridging AI-driven insights with sustainable crop improvement.

Plant molecular biology
Environmental challenges such as drought, salinity, heavy metal contamination, and nutrient deficiencies threaten global agricultural productivity and food security. These stressors drastically reduce crop yields, necessitating innovative solutions. ...

Machine learning and multi-omics integration reveal TRPV2 as a central regulator in bicuspid aortic valve calcification.

Biochemical and biophysical research communications
BACKGROUND: Bicuspid aortic valve (BAV), the most common congenital heart defect, is strongly predisposed to early calcification, yet the molecular drivers remain poorly defined. This study aims to identify the functional role of transient receptor p...

DEHP promotes psoriasis via immune modulation and direct molecular interactions: Evidence from epidemiology, multi-omics, and structural simulation.

The Science of the total environment
Di (2-ethylhexyl) phthalate (DEHP), a widely used plasticizer with known immunotoxic effects, has been suspected of aggravating inflammatory skin conditions, yet its role in autoimmune diseases such as psoriasis remains poorly defined. In this study,...

Investigation into the molecular mechanism of obesity: an integrated approach of multi-omics analysis, machine learning and experimental validation.

Journal of translational medicine
BACKGROUND: Obesity has emerged as a major global public health challenge and poses a significant threat to human health. Despite extensive research, the mechanisms underlying its pathological progression remain elusive.

Single-cell multi-omics uncovers CPS1 as a breast cancer immune evasion therapeutic target.

Scientific reports
Despite significant advances in early detection and therapeutic interventions, breast cancer persists as the most frequently diagnosed malignancy and the leading cause of cancer-related deaths among women globally. Although multiple prognostic signat...

Integrative transcriptomic and genomic insights into diabetic kidney disease: evidence from multi-omics analysis and experimental validation.

Renal failure
Diabetic kidney disease (DKD) remains a critical challenge in diabetes management, necessitating a deep understanding of its molecular underpinnings for better diagnosis and treatment strategies. This study was conducted to identify and validate nove...

Multi-omics reveal critical roles of phosphatidylcholine and sphingomyelin in antipsychotic efficacy for schizophrenia.

Signal transduction and targeted therapy
Nearly 30% of patients with schizophrenia respond inadequately to current antipsychotics, with unclear markers and mechanisms of antipsychotic efficacy. A total of 208 patients with schizophrenia treated for 6 weeks with oral paliperidone were analyz...

Integrated multi-omics and machine learning approach reveals the mechanism of nicotinamide alleviating PFOS-induced hepatotoxicity.

Food & function
: Perfluorooctane sulphonate (PFOS) is a persistent environmental contaminant with well-documented hepatotoxic properties. Nicotinamide, the amide derivative of vitamin B3, is widely utilized as a nutritional supplement and exerts multiple biological...