AIMC Topic: Plasma
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Intelligent Microfluidics for Plasma Separation: Integrating Computational Fluid Dynamics and Machine Learning for Optimized Microchannel Design.
Biosensors
Feb 6, 2025
Efficient separation of blood plasma and Packed Cell Volume (PCV) is vital for rapid blood sensing and early disease detection, especially in point-of-care and resource-limited environments. Conventional centrifugation methods for separation are reso...
Protocol to identify biomarkers in patients with post-COVID condition using multi-omics and machine learning analysis of human plasma.
STAR protocols
Apr 27, 2024
Here, we present a workflow for analyzing multi-omics data of plasma samples in patients with post-COVID condition (PCC). Applicable to various diseases, we outline steps for data preprocessing and integrating diverse assay datasets. Then, we detail ...
An all-two-dimensional Fe-FET retinomorphic sensor based on the novel gate dielectric InSeO.
Nanoscale
Jun 30, 2023
Two-dimensional (2D) ferroelectric field-effect transistors (Fe-FETs) have attracted extensive interest as a competitive platform for implementing future-generation functional electronics, including digital memory and brain-inspired computing circuit...
Development of a 2D-QSAR Model for Tissue-to-Plasma Partition Coefficient Value with High Accuracy Using Machine Learning Method, Minimum Required Experimental Values, and Physicochemical Descriptors.
European journal of drug metabolism and pharmacokinetics
Jun 2, 2023
BACKGROUND: The demand for physiologically based pharmacokinetic (PBPK) model is increasing currently. New drug application (NDA) of many compounds is submitted with PBPK models for efficient drug development. Tissue-to-plasma partition coefficient (...
Integrated Pipeline of Rapid Isolation and Analysis of Human Plasma Exosomes for Cancer Discrimination Based on Deep Learning of MALDI-TOF MS Fingerprints.
Analytical chemistry
Jan 13, 2022
Plasma exosomes have shown great potential for liquid biopsy in clinical cancer diagnosis. Herein, we present an integrated strategy for isolating and analyzing exosomes from human plasma rapidly and then discriminating different cancers excellently ...
Direct Comparison of Total Clearance Prediction: Computational Machine Learning Model versus Bottom-Up Approach Using In Vitro Assay.
Molecular pharmaceutics
Jun 12, 2020
The in vitro-in vivo extrapolation (IVIVE) approach for predicting total plasma clearance (CL) has been widely used to rank order compounds early in discovery. More recently, a computational machine learning approach utilizing physicochemical descrip...
Pharmacokinetics
Administration, Intravenous
Plasma
Microsomes, Liver
Hepatocytes
Permeability
Metabolic Clearance Rate
Membranes, Artificial
Liver
Blood Proteins
Pharmaceutical Preparations
Dogs
Models, Biological
Madin Darby Canine Kidney Cells
Protein Binding
Rats
Rats, Sprague-Dawley
Machine Learning
Animals
Male
Humans
Plasma and cerebrospinal fluid population pharmacokinetic modeling and simulation of meropenem after intravenous and intrathecal administration in postoperative neurosurgical patients.
Diagnostic microbiology and infectious disease
Aug 17, 2018
Combined intravenous and local intrathecal administration of meropenem in patients after craniotomy is widely used to treat intracranial infections. However, the optimal dosing regimen of meropenem has not been investigated, posing a risk to treatmen...
Identification of Clinically Meaningful Plasma Transfusion Subgroups Using Unsupervised Random Forest Clustering.
AMIA ... Annual Symposium proceedings. AMIA Symposium
Apr 16, 2018
Statistical techniques such as propensity score matching and instrumental variable are commonly employed to "simulate" randomization and adjust for measured confounders in comparative effectiveness research. Despite such adjustments, the results of t...
Quantification and pharmacokinetics of alpinetin in rat plasma by UHPLC-MS/MS using protein precipitation coupled with dilution approach to eliminate matrix effects.
Journal of pharmaceutical and biomedical analysis
Dec 27, 2017
Alpinetin, a bioactive flavonoid, has attracted great attention due to its diverse therapeutic effects, namely anti-oxidant, anti-tumor and anti-inflammatory effects with low systemic toxicity. Various determination methods have been developed in qua...
Evaluation of a human adenovirus viral load assay using the Altona RealStar® PCR test.
Diagnostic microbiology and infectious disease
Dec 2, 2017
This study evaluated the performance of the Altona Diagnostics RealStar® Adenovirus Research Use Only (RUO) real-time PCR reagents for HAdV quantitation in plasma samples from immunodeficient patients. The assay was linear from 2.30-9.17 log copies/m...
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