AIMC Topic: Prospective Studies

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Comparative analysis of pre-transcatheter aortic valve implantation CTA protocols: Optimizing radiation dose and contrast volume.

International journal of cardiology
BACKGROUND: To establish the most effective and safe pre-transcatheter aortic valve implantation (TAVI) CT angiography (CTA) protocol by comparing two approaches in terms of image quality, radiation and contrast dose.

Inflammatory biomarkers as predictors for unlocking antidepressant efficacy: Assessing predictive value and risk stratification in major depressive disorder in a prospective longitudinal study.

Journal of affective disorders
BACKGROUND: Major depressive disorder (MDD) is characterized by significant heterogeneity in treatment response, with inflammation hypothesized to play a role in its pathophysiology. Peripheral inflammatory biomarkers, such as the neutrophil-to-lymph...

Designing Supportive Dashboards for Crisis Response to Protect Vulnerable Populations: A Qualitative Study.

Studies in health technology and informatics
INTRODUCTION: The COVID-19 pandemic exposed both direct and collateral health impacts especially on vulnerable populations, underscoring the need for more targeted and equitable crisis response strategies. Health-related dashboards could support bett...

Functional Consequences of Tinnitus in Military Service Members.

American journal of audiology
PURPOSE: Numerous individuals in the United States are bothered enough by tinnitus that it affects normal daily activities, including sleep and concentration. There is a high prevalence of self-reported bothersome tinnitus in the U.S. military, and t...

Improving Clinically Significant Prostate Cancer Detection with a Multimodal Machine Learning Approach: A Large-Scale Multicenter Study.

Radiology. Imaging cancer
Purpose To develop and prospectively validate a clinical and radiologic model to predict clinically significant prostate cancer (csPCa) using biparametric MRI (bpMRI). Materials and Methods Retrospective data (acquired before March 31, 2022) from 12 ...

Comparison of dengue, chikungunya, and Zika among children in Nicaragua across 18 years: a single-centre, prospective cohort study.

The Lancet. Child & adolescent health
BACKGROUND: Dengue, chikungunya, and Zika are diseases of major human concern. Differential diagnosis of these three diseases is complicated in children and adolescents due to overlapping clinical features (signs, symptoms, and complete blood count r...

GPSai: A Clinically Validated AI Tool for Tissue of Origin Prediction during Routine Tumor Profiling.

Cancer research communications
UNLABELLED: A subset of cancers present with unclear or potentially incorrect primary histopathologic diagnoses, including cancers of unknown primary (CUP). We aimed to develop and validate an artificial intelligence (AI) tool, Genomic Probability Sc...

Impact of three-dimensional prostate models during robot-assisted radical prostatectomy on surgical margins and functional outcomes.

BJU international
BACKGROUND: Robot-assisted radical prostatectomy (RARP) is the standard surgical procedure for the treatment of prostate cancer. RARP requires a trade-off between performing a wider resection in order to reduce the risk of positive surgical margins (...

SPACE: Subregion Perfusion Analysis for Comprehensive Evaluation of Breast Tumor Using Contrast-Enhanced Ultrasound-A Retrospective and Prospective Multicenter Cohort Study.

Ultrasound in medicine & biology
OBJECTIVE: To develop a dynamic contrast-enhanced ultrasound (CEUS)-based method for segmenting tumor perfusion subregions, quantifying tumor heterogeneity, and constructing models for distinguishing benign from malignant breast tumors.