AIMC Topic: Rats

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Mechanobiology-guided machine learning models for predicting long bone fracture healing across diverse scenarios.

Computers in biology and medicine
BACKGROUND: Fracture healing is a complex, time-dependent process governed by biological and mechanical factors, including implant properties. While finite element (FE) modeling provides detailed mechanobiological insights into this process, its comp...

Identification of inflammation-related biomarkers and therapeutic targets for neurogenic bladder fibrosis via multi-omics analysis.

Computers in biology and medicine
Inflammatory responses play a crucial role in the progression of pediatric neurogenic bladder (NB)-associated fibrosis; however, their specific contributions remain poorly understood. This study aimed to identify inflammation-related biomarkers for d...

Effects of vascular endothelial cells on the neurite outgrowth of nerve cells.

Journal of bioscience and bioengineering
The vascular and neuronal networks are structurally complex and highly branched. These networks play an important role in supplying oxygen and sending signals to the tissues and organs in the body. This study proposes procedures to prepare in vitro n...

Estimation of postmortem interval under different ambient temperatures based on multi-organ metabolomics and machine learning algorithm.

International journal of legal medicine
In forensic practice, the estimation of postmortem interval has been a persistent challenge. Recently, there has been an increasing utilization of metabolomics techniques combined with machine learning methods for postmortem interval estimation. When...

Evaluating safe infrared neural stimulation parameters: Calcium dynamics and excitotoxicity thresholds in dorsal root ganglia neurons.

Journal of neuroscience methods
BACKGROUND: As a promising neural stimulation technique, infrared neural stimulation (INS) has recently gained significant attention due to its ability to stimulate neuronal activities without needing exogenous agents. NIR light is absorbed by water ...

Genetic Neural Network-Assisted Natural Deep Eutectic Solvent Extraction for Enhanced Bioactive Yield from Folium Mori with Cytotoxicity Profiling.

Journal of chromatographic science
Natural deep eutectic solvents (NaDESs) was efficient and green for componential extraction of traditional Chinese medicine compared to conventional organic solvents. In this study, a total of nine NaDESs were synthesized and screened, and Proline-Ur...

Automated Microbubble Discrimination in Ultrasound Localization Microscopy by Vision Transformer.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control
Ultrasound localization microscopy (ULM) has revolutionized microvascular imaging by breaking the acoustic diffraction limit. However, different ULM workflows depend heavily on distinct prior knowledge, such as the impulse response and empirical sele...

Integrating single-cell analysis and machine learning to identify COPD hub genes and explore the intervention mechanism of effective component compatibility of Bufei Yishen formula III.

Journal of ethnopharmacology
ETHNOPHARMACOLOGICAL RELEVANCE: Chronic obstructive pulmonary disease (COPD) is a prevalent condition that poses a major threat to public health. Endothelial cells play a critical role in COPD pathogenesis. Recent evidence suggests that the effective...

Mechanically Matched Heart-on-a-Chip Platform Mediated Maturation of Excitation-Contraction Coupling.

ACS nano
Heart-on-a-chip (HOC) platforms play a pivotal role in cardiac research, yet existing models suffer from mechanical mismatch between the soft myocardial tissue, sensors, and substrate, leading to impaired myocardial function and compromised data capt...

Machine learning to detect schedules using spatiotemporal data of behavior: A proof of concept.

Journal of the experimental analysis of behavior
Traditionally, the experimental analysis of behavior has relied on the single discrete response paradigm (e.g., key pecks, lever presses, screen clicks) to identify behavioral patterns. However, the development and availability of new technology allo...