AIMC Topic: RAW 264.7 Cells

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Morphology-based classification of mycobacteria-infected macrophages with convolutional neural network: reveal EsxA-induced morphologic changes indistinguishable by naked eyes.

Translational research : the journal of laboratory and clinical medicine Jun 28, 2019
EsxA is an essential virulence factor for Mycobacterium tuberculosis (Mtb) pathogenesis as well as an important biomarker for Mtb detection. In this study, we use light microscopy and deep learning-based image analysis to classify the morphologic cha...
Neural Networks, Computer Macrophages Animals Mice Humans Mycobacterium marinum A549 Cells Bacterial Proteins Virulence Factors RAW 264.7 Cells
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Isolation and identification of immunomodulatory selenium-containing peptides from selenium-enriched rice protein hydrolysates.

Food chemistry Sep 20, 2018
The RAW264.7 cell model was employed to screen immunomodulatory selenium-containing peptides from selenium-enriched rice protein hydrolysates (SPHs). Moreover, the selenium-containing peptides of high-activity protein hydrolysates were purified by Se...
Macrophages Oryza Selenomethionine Tandem Mass Spectrometry Animals Selenium Peptides Sonication Immunologic Factors Mice RAW 264.7 Cells Amino Acid Sequence Nitric Oxide Metalloendopeptidases Chromatography, High Pressure Liquid Cell Proliferation Protein Hydrolysates
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Noninvasive detection of macrophage activation with single-cell resolution through machine learning.

Proceedings of the National Academy of Sciences of the United States of America Mar 6, 2018
We present a method enabling the noninvasive study of minute cellular changes in response to stimuli, based on the acquisition of multiple parameters through label-free microscopy. The retrieved parameters are related to different attributes of the c...
Spectrum Analysis, Raman Lipopolysaccharides Dose-Response Relationship, Drug Microscopy, Fluorescence Single-Cell Analysis Image Processing, Computer-Assisted Mice Progesterone Models, Biological RAW 264.7 Cells Macrophage Activation Machine Learning Animals
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Gastro-protective effect of edible plant Artemisia argyi in ethanol-induced rats via normalizing inflammatory responses and oxidative stress.

Journal of ethnopharmacology Dec 20, 2017
PHARMACOLOGICAL RELEVANCE: Artemisia argyi, a kind of ethnic drug, has a long-term use on gastric diseases and syndromes.
Disease Models, Animal Anti-Inflammatory Agents Artemisia Plants, Medicinal Inflammation Mediators RAW 264.7 Cells Free Radicals Cytoprotection Rats, Wistar Malondialdehyde Superoxide Dismutase Ethanol Macrophages Animals Oxidative Stress Mice Phytotherapy Antioxidants Anti-Ulcer Agents Plant Extracts Gastric Mucosa Stomach Ulcer
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Elevation of serum pyruvate kinase M2 (PKM2) in IBD and its relationship to IBD indices.

Clinical biochemistry Dec 19, 2017
OBJECTIVES: Endoscopy remains the gold standard to diagnose and evaluate inflammatory bowel disease (IBD) activity. Current biomarkers or their combinations cannot adequately predict IBD risk, diagnosis, progression or relapse, and response to therap...
Pyruvate Kinase Adult Humans Gastrointestinal Microbiome Animals Biomarkers Dysbiosis Male Inflammatory Bowel Diseases Caco-2 Cells Mice Female RAW 264.7 Cells
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Inhibitory activity of linarin on osteoclastogenesis through receptor activator of nuclear factor κB ligand-induced NF-κB pathway.

Biochemical and biophysical research communications Dec 18, 2017
Linarin, a natural flavonoid glycoside widely found in plants, has been reported to possess anti-inflammation, neuroprotection and osteogenic properties. However, its impact on osteoclast remains unclear. In the present study, the effects of linarin ...
Dose-Response Relationship, Drug NF-kappa B Osteogenesis RAW 264.7 Cells Osteoblasts Glycosides Mice Signal Transduction RANK Ligand Mice, Inbred C57BL Cells, Cultured Macrophages Animals
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Tribulus terrestris L. Extract Alleviates Atherosclerosis by Suppressing TNF-α-Mediated Macrophage Inflammation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology Aug 15, 2025
Atherosclerosis (AS) is a major contributor to cardiovascular disease. In traditional Chinese medicine, Tribulus terrestris L., or Baijili (BJL), has shown therapeutic effects on inflammation and cardiovascular issues. Our prior research indicated th...
Male Molecular Docking Simulation Mice Plant Extracts Tumor Necrosis Factor-alpha Macrophages Animals Atherosclerosis RAW 264.7 Cells Apolipoproteins E Tribulus Inflammation Mice, Inbred C57BL Diet, High-Fat Mice, Knockout
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Exploration of Active Substances and Its Potential Mechanism of Gancao Fuzi Decoction on Inflammatory Based on Metabolomics and Network Pharmacology.

Rapid communications in mass spectrometry : RCM May 30, 2025
Gancao Fuzi decoction (GCFZT) is a traditional Chinese formula, which has been commonly used in clinical practice to treat inflammatory diseases. However, the active substance of GCFZT in the treatment of inflammation is not fully clarified. In this ...
Network Pharmacology Signal Transduction Metabolomics Drugs, Chinese Herbal Animals NF-kappa B Anti-Inflammatory Agents Mice Chromatography, High Pressure Liquid Inflammation Tandem Mass Spectrometry RAW 264.7 Cells
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Ajudecumin A from Ajuga ovalifolia var. calantha exhibits anti-inflammatory activity in lipopolysaccharide-activated RAW264.7 murine macrophages and animal models of acute inflammation.

Pharmaceutical biology Dec 1, 2018
CONTEXT: Ajuga ovalifolia Bur. et Franch. var. calantha (Diels) C. Y. Wu et C. Chen (Labiatae), a traditional Chinese medicine, has been used to treat several inflammatory diseases.
Lipopolysaccharides Mice Dose-Response Relationship, Drug Ajuga Plant Extracts Macrophages Anti-Inflammatory Agents Animals Inflammation RAW 264.7 Cells Male Disease Models, Animal
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