AIMC Topic: RNA, Messenger
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Exopolysaccharides of Lactobacillus reuteri: Their influence on adherence of E. coli to epithelial cells and inflammatory response.
Carbohydrate polymers
Dec 17, 2015
The aim of the study was to characterize exopolysaccharides (EPS) originated from Lactobacillus reuteri strain DSM 17938 (EPS-DSM17938) and L. reuteri strain L26 Biocenol™ (EPS-L26) and evaluate their influence on adherence of enterotoxigenic Escheri...
Computational identification of piRNA targets on mouse mRNAs.
Bioinformatics (Oxford, England)
Dec 16, 2015
MOTIVATION: PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that are highly abundant in the germline. One important role of piRNAs is to defend genome integrity by guiding PIWI proteins to silence transposable elements (TEs), whic...
Changes in brain ribonuclease (BRB) messenger RNA in granulosa cells (GCs) of dominant vs subordinate ovarian follicles of cattle and the regulation of BRB gene expression in bovine GCs.
Domestic animal endocrinology
Oct 31, 2015
Brain ribonuclease (BRB) is a member of the ribonuclease A superfamily that is constitutively expressed in a range of tissues and is the functional homolog of human ribonuclease 1. This study was designed to characterize BRB gene expression in granul...
Cytotoxic response of platinum-coated gold nanorods in human breast cancer cells at very low exposure levels.
Environmental toxicology
Apr 6, 2015
Because of unique optical behavior gold nanorods (GNRs) have attracted attention for the application in biomedical field such as bio-sensing, bio-imaging and hyperthermia. However, toxicological response of GNRs is controversial due to their differen...
Reactive Oxygen Species
Up-Regulation
Real-Time Polymerase Chain Reaction
Caspase 9
Humans
Caspase 3
Nanotubes
Platinum
RNA, Messenger
G1 Phase Cell Cycle Checkpoints
Female
Acetylcysteine
Proto-Oncogene Proteins c-bcl-2
Particle Size
Apoptosis
Breast Neoplasms
MCF-7 Cells
Down-Regulation
Gold
Membrane Potential, Mitochondrial
ViralmiR: a support-vector-machine-based method for predicting viral microRNA precursors.
BMC bioinformatics
Jan 21, 2015
BACKGROUND: microRNAs (miRNAs) play a vital role in development, oncogenesis, and apoptosis by binding to mRNAs to regulate the posttranscriptional level of coding genes in mammals, plants, and insects. Recent studies have demonstrated that the expre...
An improved poly(A) motifs recognition method based on decision level fusion.
Computational biology and chemistry
Dec 30, 2014
Polyadenylation is the process of addition of poly(A) tail to mRNA 3' ends. Identification of motifs controlling polyadenylation plays an essential role in improving genome annotation accuracy and better understanding of the mechanisms governing gene...
Molecular classification of amyotrophic lateral sclerosis by unsupervised clustering of gene expression in motor cortex.
Neurobiology of disease
Dec 10, 2014
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and ultimately fatal neurodegenerative disease, caused by the loss of motor neurons in the brain and spinal cord. Although 10% of ALS cases are familial (FALS), the majority are sporadic (S...
TransCNN: A novel architecture combining transformer and TextCNN for detecting N4-acetylcytidine sites in human mRNA.
Analytical biochemistry
Aug 1, 2025
N4-acetylcytidine (ac4C), a pivotal post-transcriptional RNA modification, is central to understanding transcriptional regulation and diverse biological processes. As a key determinant of RNA structural stability and functional regulation, ac4C has b...
Assessing Substrate Scope of the Cyclodehydratase LynD by mRNA Display-Enabled Machine Learning Models.
Biochemistry
Jul 1, 2025
Many members of the broad family of enzymes, known as YcaOs have been shown to install azoline heterocycles post-translationally into peptide substrates. These moieties can help rigidify structures and contribute to the potent bioactivities of the ev...
ENsiRNA: A Multimodality Method for siRNA-mRNA and Modified siRNA Efficacy Prediction Based on Geometric Graph Neural Network.
Journal of molecular biology
Jun 15, 2025
With the rise of small interfering RNA (siRNA) as a therapeutic tool, effective siRNA design is crucial. Current methods often emphasize sequence-related features, overlooking structural information. To address this, we introduce ENsiRNA, a multimoda...
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