UNLABELLED: Combination therapies are one potential approach to improve the outcomes of patients with relapsed/refractory (R/R) disease. However, comprehensive testing in scarce primary patient material is hampered by the many drug combination possib...
Resistance to chemotherapy of pancreatic ductal adenocarcinoma (PDAC) is largely driven by intratumoral heterogeneity (ITH) due to tumor cell plasticity and clonal diversity. To develop alternative strategies to overcome this defined mechanism of res...
Single-cell sequencing technology has profoundly revolutionized the field of cancer genomics, enabling researchers to explore gene expression profiles at the resolution of individual cells. Despite its extensive applications in the study of cancer ge...
MOTIVATION: Clustering cells into subpopulations is one of the most crucial tasks in single-cell RNA sequencing (scRNA-seq) data analysis, which provides support for biological research at cellular level. With the development of graph neural networks...
BACKGROUND: The molecular and genetic mechanisms underlying vascular calcification remain unclear. This study aimed to determine the differences in calcification marker-related gene expression in macrophages.
Single-cell RNA-sequencing (scRNA-seq) coupled with robust computational analysis facilitates the characterization of phenotypic heterogeneity within tumors. Current scRNA-seq analysis pipelines are capable of identifying a myriad of malignant and no...
Raman spectroscopy provides intrinsic biochemical profiles of all cellular biomolecules in a segmented manner, promising nondestructive and label-free phenotyping at the single-cell level. However, current analytical methods rarely utilize spectral b...
Journal of cellular and molecular medicine
Jun 1, 2025
Oral cancer is among the most prevalent malignant tumours worldwide; prognosis can be affected by several factors, including molecular subtypes, immune microenvironment and clinical characteristics. In this study, we aimed to apply machine learning m...
BACKGROUND: Gallbladder cancer (GBC) is a rare but aggressive malignancy, often detected late due to early asymptomatic stages. Understanding cellular and molecular changes from normal tissue to high-grade intraepithelial neoplasia (HGIN) and invasiv...
OBJECTIVE: To identify blood-based biomarkers and therapeutic targets for Alzheimer's disease (AD) by leveraging single-cell RNA sequencing (scRNA-seq) data from peripheral blood mononuclear cells (PBMCs) and advanced deep learning techniques.
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