AIMC Topic: Technology, Pharmaceutical
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A novel method for the production of core-shell microparticles by inverse gelation optimized with artificial intelligent tools.
International journal of pharmaceutics
Jan 16, 2018
Numerous studies have been focused on hydrophobic compounds encapsulation as oils. In fact, oils can provide numerous health benefits as synergic ingredient combined with other hydrophobic active ingredients. However, stable microparticles for pharma...
Transparent predictive modelling of the twin screw granulation process using a compensated interval type-2 fuzzy system.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Dec 27, 2017
In this research, a new systematic modelling framework which uses machine learning for describing the granulation process is presented. First, an interval type-2 fuzzy model is elicited in order to predict the properties of the granules produced by t...
Stability of infliximab solutions in different temperature and dilution conditions.
Journal of pharmaceutical and biomedical analysis
Dec 18, 2017
Infliximab is a monoclonal antibody widely used for the treatment of inflammatory diseases. Over the past few years, many studies have assessed that monoclonal antibodies are prone to aggregation under stress conditions. The aim of this study was to ...
Drug Compounding
Osmolar Concentration
Pharmaceutical Solutions
Technology, Pharmaceutical
Chromatography, Ion Exchange
Temperature
Infliximab
Antirheumatic Agents
Nephelometry and Turbidimetry
Biosimilar Pharmaceuticals
Time Factors
Protein Stability
Protein Aggregates
Nanoparticles
Peptide Mapping
Drug Stability
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Chromatography, Gel
On the Design of a Fuzzy Logic-Based Control System for Freeze-Drying Processes.
Journal of pharmaceutical sciences
Sep 28, 2016
This article is focused on the design of a fuzzy logic-based control system to optimize a drug freeze-drying process. The goal of the system is to keep product temperature as close as possible to the threshold value of the formulation being processed...
Implementation of an artificial neural network as a PAT tool for the prediction of temperature distribution within a pharmaceutical fluidized bed granulator.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Mar 15, 2016
In this study, a novel in-line measurement technique of the air temperature distribution during a granulation process using a conical fluidized bed was designed and built for the purpose of measuring the temperature under the Process Analytical Techn...
Formulation of Granules for Site-Specific Delivery of an Antimicrobial Essential Oil to the Animal Intestinal Tract.
Journal of pharmaceutical sciences
Dec 23, 2015
Owing to proliferation of antibiotic-resistant bacteria, the use of antibiotics for livestock growth promotion is banned in many countries and alternatives to in-feed antibiotics are needed. Cinnamon essential oil exhibits strong in vitro antibacteri...
Combination of counterpropagation artificial neural networks and antioxidant activities for comprehensive evaluation of associated-extraction efficiency of various cyclodextrins in the traditional Chinese formula Xue-Zhi-Ning.
Journal of pharmaceutical and biomedical analysis
Aug 12, 2015
Xue-Zhi-Ning (XZN) is a widely used traditional Chinese medicine formula to treat hyperlipidemia. Recently, cyclodextrins (CDs) have been extensively used to minimize problems relative to medicine bioavailability, such as low solubility and poor stab...
Optimization of controlled release nanoparticle formulation of verapamil hydrochloride using artificial neural networks with genetic algorithm and response surface methodology.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
May 16, 2015
This study was performed to optimize the formulation of polymer-lipid hybrid nanoparticles (PLN) for the delivery of an ionic water-soluble drug, verapamil hydrochloride (VRP) and to investigate the roles of formulation factors. Modeling and optimiza...
Polysorbates
Solubility
Nanomedicine
Technology, Pharmaceutical
Neural Networks, Computer
Models, Chemical
Surface Properties
Polymers
Algorithms
Calcium Channel Blockers
Kinetics
Particle Size
Computer Simulation
Chemistry, Pharmaceutical
Verapamil
Lipids
Nanoparticles
Delayed-Action Preparations
Drug Carriers
Poloxamer
Size Control in the Nanoprecipitation Process of Stable Iodine (¹²⁷I) Using Microchannel Reactor-Optimization by Artificial Neural Networks.
AAPS PharmSciTech
Feb 6, 2015
In this study, nanosuspension of stable iodine ((127)I) was prepared by nanoprecipitation process in microfluidic devices. Then, size of particles was optimized using artificial neural networks (ANNs) modeling. The size of prepared particles was eval...
Media-fill simulation tests in manual and robotic aseptic preparation of injection solutions in syringes.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
Dec 30, 2014
OBJECTIVE: The purpose of this study was to evaluate the contamination rate of media-fill products either prepared automated with a robotic system (APOTECAchemo™) or prepared manually at cytotoxic workbenches in the same cleanroom environment and by ...
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