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On the Design of a Fuzzy Logic-Based Control System for Freeze-Drying Processes.

Journal of pharmaceutical sciences
This article is focused on the design of a fuzzy logic-based control system to optimize a drug freeze-drying process. The goal of the system is to keep product temperature as close as possible to the threshold value of the formulation being processed...

Implementation of an artificial neural network as a PAT tool for the prediction of temperature distribution within a pharmaceutical fluidized bed granulator.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
In this study, a novel in-line measurement technique of the air temperature distribution during a granulation process using a conical fluidized bed was designed and built for the purpose of measuring the temperature under the Process Analytical Techn...

Development of an ANN optimized mucoadhesive buccal tablet containing flurbiprofen and lidocaine for dental pain.

Acta pharmaceutica (Zagreb, Croatia)
A novel mucoadhesive buccal tablet containing flurbiprofen (FLB) and lidocaine HCl (LID) was prepared to relieve dental pain. Tablet formulations (F1-F9) were prepared using variable quantities of mucoadhesive agents, hydroxypropyl methyl cellulose (...

Media-fill simulation tests in manual and robotic aseptic preparation of injection solutions in syringes.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
OBJECTIVE: The purpose of this study was to evaluate the contamination rate of media-fill products either prepared automated with a robotic system (APOTECAchemo™) or prepared manually at cytotoxic workbenches in the same cleanroom environment and by ...

Video tracking for high-similarity drug tablets based on reflective lightness intensity and fuzzy recognition system.

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
Video tracking of drug tablet exerts important influences on the efficiency and reliability of its mass production; this topic also becomes a difficult and targeted focus for pharmaceutical production monitory in the past several years due to the hig...

Combination of counterpropagation artificial neural networks and antioxidant activities for comprehensive evaluation of associated-extraction efficiency of various cyclodextrins in the traditional Chinese formula Xue-Zhi-Ning.

Journal of pharmaceutical and biomedical analysis
Xue-Zhi-Ning (XZN) is a widely used traditional Chinese medicine formula to treat hyperlipidemia. Recently, cyclodextrins (CDs) have been extensively used to minimize problems relative to medicine bioavailability, such as low solubility and poor stab...