This study investigated dynamic brain network changes and their genetic correlations in children with idiopathic generalized epilepsy (IGE). We included 26 children with IGE and 35 healthy controls, all participants underwent resting-state functional...
Endometriosis (EMs) and recurrent miscarriage (RM) represent major reproductive health challenges. This study investigates the involvement of endothelial-mesenchymal transition (EndMT) in these conditions through integrative bioinformatics analysis, ...
The primary aim of our study was to address the problem of transcriptomic data complexity by introducing a novel transcriptomic response index (TRI), compressing the entire transcriptomic space into a single variable, and linking it with the inhaled ...
BACKGROUND: Obesity has emerged as a major global public health challenge and poses a significant threat to human health. Despite extensive research, the mechanisms underlying its pathological progression remain elusive.
Spatial transcriptomics is a rapidly developing field of single-cell genomics that quantitatively measures gene expression while providing spatial information within tissues. A key challenge in spatial transcriptomics is identifying spatially structu...
Journal of experimental & clinical cancer research : CR
Oct 16, 2025
The high intra-patient heterogeneity in multifocal primary prostate cancer (PCa) has curtailed the efficacy of current treatment options. By employing twin biopsies from multiple lesions with matched patient-derived organoids (PDO) models, the PCa mo...
Diabetic kidney disease (DKD) remains a critical challenge in diabetes management, necessitating a deep understanding of its molecular underpinnings for better diagnosis and treatment strategies. This study was conducted to identify and validate nove...
BACKGROUND: Patients with polycystic ovary syndrome (PCOS) often experience a range of metabolic comorbidities, suggesting a potential association between PCOS and metabolic syndrome (MetS). However, this potential link has not yet been fully elucida...
BACKGROUND: Considering the complex and close-knit relationship between non-alcoholic fatty liver disease (NAFLD) and the metabolic status, this study aimed to identify lipid metabolism-related genes (LMGs), construct an effective diagnostic model, a...
BACKGROUND: Accurate staging is pivotal for tailoring treatment intensity, optimizing resource allocation, and improving long-term patient outcomes in IBD. The intestinal microbiota and transcriptional profiles emerge as critical determinants in IBD ...
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