Sepsis-associated encephalopathy (SAE) is a major complication in intensive care units, characterized by diffuse brain dysfunction due to systemic inflammation. Despite advances in critical care medicine, SAE remains a key factor in poor patient outc...
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune disease with chronic presentation, involving symmetric joints and systemic involvement. Ferroptosis is iron-dependent programmed cell death through lipid peroxide accumulation, implicated in infl...
The advancements in neuroscience research and omics technologies generate extensive data for brain-related diseases and disorders that are scattered across various manuscript repositories and databases, potentially hindering global initiatives to adv...
Stomach adenocarcinoma (STAD), the most prevalent histological subtype of gastric cancer, exhibits high heterogeneity and poor prognosis, posing significant therapeutic challenges. Parthanatos, a distinct form of regulated cell death mediated by poly...
Lymph node (LN) lymphatic endothelial cells (LEC) actively acquire and archive foreign antigens. Here, we address questions of how LECs achieve durable antigen archiving and whether LECs with high levels of antigen express unique transcriptional prog...
BACKGROUND: Drought is a global challenge that severely restricts crop yields and threatens food security. Plants respond to drought stress by modulating gene expression before visible phenotypic changes occur. However, most studies of drought resist...
OBJECTIVE: To investigate the causal relationship between serotonin levels, adenosine deaminase (ADA) activity and multiple sclerosis (MS) progression using an integrative multi-omics approach.
Oestrogen receptor alpha (ERα)-positive (ER+) breast cancers are driven by the binding of 17β-oestradiol (E2) to ERα, which transcriptionally regulates target genes. Although microarrays and conventional RNA sequencing have identified E2 target genes...
Keloid scarring and Metabolic Syndrome (MS) are distinct conditions marked by chronic inflammation and tissue dysregulation, suggesting shared pathogenic mechanisms. Identifying common regulatory genes could unveil novel therapeutic targets. Methods...
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