AIMC Topic: Urinary Bladder Neoplasms

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Deep learning-based spatial analysis on tumor and immune cells of pathology images predicts MIBC prognosis.

PloS one
OBJECTIVE: Muscle-invasive bladder cancer (MIBC) is a highly aggressive disease with a poor prognosis. This study aims to explore the correlation between the spatial distribution of lymphocyte aggregates and the prognosis of MIBC using deep learning.

Graph theoretic and machine learning approaches in molecular property prediction of bladder cancer therapeutics.

Scientific reports
This work introduces a hybrid computational approach in which degree-based topological descriptors are harnessed with the aid of advanced regression models and artificial neural networks (ANNs) to predict the crucial physicochemical properties of 17 ...

Developing angiogenesis-related prognostic biomarkers and therapeutic strategies in bladder cancer using deep learning and machine learning.

Scientific reports
Bladder cancer (BLCA) is a prevalent urological malignancy that exhibits a high degree of tumor heterogeneity and morbidity. Tumor angiogenesis, a vital hallmark of cancer, greatly influences the tumor microenvironment (TME). The emergence of anti-an...

Identification and single-cell analysis of prognostic genes related to mitochondrial and neutrophil extracellular traps in bladder cancer.

Scientific reports
The development of bladder cancer (BLCA) is associated with mitochondrial dysfunction and neutrophil extracellular traps (NETs); however, the relationship between mitochondrial function and NET formation in BLCA remains poorly understood. In this stu...

Preoperative prediction of severe short-term complications in patients with bladder cancer undergoing radical cystectomy.

Surgical oncology
BACKGROUND AND OBJECTIVE: Radical cystectomy (RC) is associated with a high risk of postoperative complications. The prediction of individual patient risk for severe complications can facilitate preoperative shared decision-making. Patients with elev...

Magnetic-Driven Hydrogel Robots Loaded with Mitomycin for Active Therapy of Bladder Cancer.

ACS applied materials & interfaces
Intravesical drug instillation is a common treatment for bladder cancer, but it suffers from poor targeting and suboptimal patient experience due to the influence of gravity. Here, we innovatively designed a bladder cancer treatment method using sodi...

Development of a machine learning-based model to predict urethral recurrence following radical cystectomy: a multicentre retrospective study and updated meta-analysis.

Scientific reports
Urethral recurrence (UR) following radical cystectomy for bladder cancer represents an aggressive disease failure with typically poor survival outcomes. Our study aimed to assess the predictive risk factors for UR, to develop and validate an easy-to-...

Unsupervised learning-based quantitative analysis of CT intratumoral subregions predicts risk stratification of bladder cancer patients.

BMC medicine
BACKGROUND: Preoperative diagnosis of muscle invasion and American Joint Committee on Cancer (AJCC) stage plays a crucial role in guiding treatment strategies for bladder cancer (BCa). Utilizing quantitative analysis of tumor subregions via CT imagin...

Disulfide bond-related gene signature development for bladder cancer prognosis prediction and immune microenvironment characterization.

Scientific reports
Bladder cancer is the fourth most common malignant tumor in men, with limited therapeutic biomarkers and heterogeneous responses to immunotherapy. Disulfide bond-driven cell death has emerged as a critical regulator of tumor progression and immune mi...

Identification of a panel of volatile organic compounds in urine for early detection of for bladder cancer.

Scientific reports
The absence of specific markers makes early detection of bladder cancer (BC) challenging. Recent studies have reported the reliable diagnostic significance of volatile organic compounds (VOCs) in several cancers. This study aimed to investigate wheth...