Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jul 30, 2024
Cross-species prediction of TF binding remains a major challenge due to the rapid evolutionary turnover of individual TF binding sites, resulting in cross-species predictive performance being consistently worse than within-species performance. In thi...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jul 23, 2024
Mechanotherapy has emerged as a promising treatment for tissue injury. However, existing robots for mechanotherapy are often designed on intuition, lack remote and wireless control, and have limited motion modes. Herein, through topology optimization...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jul 21, 2024
The δ-conotoxins, a class of peptides produced in the venom of cone snails, are of interest due to their ability to inhibit the inactivation of voltage-gated sodium channels causing paralysis and other neurological responses, but difficulties in thei...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jul 15, 2024
Rock-climbing robots have significant potential in fieldwork and planetary exploration. However, they currently face limitations such as a lack of stability and adaptability on extreme terrains, slow locomotion, and single functionality. This study i...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jul 8, 2024
As a significant infectious disease in livestock, porcine reproductive and respiratory syndrome (PRRS) imposes substantial economic losses on the swine industry. Identification of diagnostic markers and therapeutic targets has been a focal challenge ...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jul 8, 2024
Hyperuricemia (HUA) has emerged as the second most prevalent metabolic disorder characterized by prolonged and asymptomatic period, triggering gout and metabolism-related outcomes. Early detection and prognosis prediction for HUA and gout are crucial...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jun 25, 2024
Tremendous popularity is observed for multifunctional flexible electronics with appealing applications in intelligent electronic skins, human-machine interfaces, and healthcare sensing. However, the reported sensing electronics, mostly can hardly pro...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jun 24, 2024
Surface-enhanced Raman scattering (SERS) imaging technology faces significant technical bottlenecks in ensuring balanced spatial resolution, preventing image bias induced by substrate heterogeneity, accurate quantitative analysis, and substrate prepa...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jun 23, 2024
Mesoscopic photoacoustic imaging (PAI) enables label-free visualization of vascular networks in tissues with high contrast and resolution. Segmenting these networks from 3D PAI data and interpreting their physiological and pathological significance i...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jun 21, 2024
Constructing discriminative representations of molecules lies at the core of a number of domains such as drug discovery, chemistry, and medicine. State-of-the-art methods employ graph neural networks and self-supervised learning (SSL) to learn unlabe...