This study aimed to produce a novel deep learning (DL) model for the classification of subjects with Alzheimer's disease (AD), mild cognitive impairment (MCI) subjects and healthy ageing (HA) subjects using resting-state scalp electroencephalogram (E...
IEEE/ACM transactions on computational biology and bioinformatics
Jun 3, 2021
The aim of this study is to develop a computer-aided diagnosis system with a deep-learning approach for distinguishing "Mild Cognitive Impairment (MCI) due to Alzheimer's Disease (AD)" patients among a list of MCI patients. In this system we are usin...
Brain pathology (Zurich, Switzerland)
May 19, 2021
People who have Alzheimer's disease neuropathologic change (ADNC) typically associated with dementia but not the associated cognitive decline can be considered to be "resilient" to the effects of ADNC. We have previously reported lower neocortical le...
Alzheimer's disease (AD) is known as one of the major causes of dementia and is characterized by slow progression over several years, with no treatments or available medicines. In this regard, there have been efforts to identify the risk of developin...
Combining multimodal biomarkers could help in the early diagnosis of Alzheimer's disease (AD). We included 304 cognitively normal individuals from the INSIGHT-preAD cohort. Amyloid and neurodegeneration were assessed on F-florbetapir and F-fluorodeox...
White matter hyperintensities (WMHs) are abnormal signals within the white matter region on the human brain MRI and have been associated with aging processes, cognitive decline, and dementia. In the current study, we proposed a U-Net with multi-scale...
Computational and mathematical methods in medicine
Apr 27, 2021
The automatic diagnosis of Alzheimer's disease plays an important role in human health, especially in its early stage. Because it is a neurodegenerative condition, Alzheimer's disease seems to have a long incubation period. Therefore, it is essential...
Computational and mathematical methods in medicine
Apr 23, 2021
Using strategies that obtain biomarkers where early symptoms coincide, the early detection of Alzheimer's disease and its complications is essential. Electroencephalogram is a technology that allows thousands of neurons with equal spatial orientation...
We evaluated the utility of leucocyte epigenomic-biomarkers for Alzheimer's Disease (AD) detection and elucidates its molecular pathogeneses. Genome-wide DNA methylation analysis was performed using the Infinium MethylationEPIC BeadChip array in 24 l...
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