AIMC Topic: Animals

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Melatonin Alleviates Retina Angiogenesis by Targeting Fibronectin and the VEGF Pathway.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Diabetic retinopathy (DR) and retinopathy of prematurity (ROP) continue to be significant causes of vision impairment despite the well-established role of vascular endothelial growth factor (VEGF) in pathological angiogenesis. We still need to deeply...

Ptgs2+ CPTC Function as a "Force-Immune Axis" by Responding to Acupuncture and Mediating M2 Macrophage Activation for Anti-Inflammatory Effects.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Recent advancements have highlighted the imperative for cytological exploration of fascial tissues. Telocytes, specialized interstitial cells found in connective tissues such as fascia, have garnered significant attention. Our study explored the cell...

Progress toward Multianalyte Neurochemical Detection: Techniques and Applications.

ACS chemical neuroscience
Brain function is shaped by the coordinated activity of billions of neurons. The neurotransmitters and neuromodulators released from these neurons work together to modulate circuit function and, ultimately, behavior. Electroanalytical technologies ar...

Heterogeneous Driving Effects Guide Personalized Tumor Treatments Targeting N6-Methyladenosine.

Cancer research
UNLABELLED: Alterations to N6-methyladenosine (m6A) modifications can promote malignant progression by modulating gene expression through regulation of transcript metabolism. Quantifying the causal impact of m6A dysregulation at the population level ...

Detection and classification of meat freshness using an optimized deep learning method.

Food chemistry
Accurate assessment of meat freshness is critical for ensuring food safety, reducing waste, and maintaining quality control in the food industry. Efficient classification of meat into categories such as fresh, half-fresh, and spoiled is essential for...

Beetle-inspired responsive photonic microgel assemblies for multi-sensing enhanced by machine learning.

Biosensors & bioelectronics
Bioinspired photonic hydrogels hold promise as sensors; however, their use in triple-analyte sensing optical devices has been minimally explored. Temperature, serum Fe levels, and X-ray doses are critical factors for predicting and monitoring medical...

DPP-IV inhibitory peptides from highland barley via machine learning and multi-scale validation.

Food chemistry
Highland barley has shown potential in regulating blood glucose and may serve as a natural source of dipeptidyl peptidase-IV (DPP-IV) inhibitors. In this study, machine learning (Gradient Boosting Decision Trees) and virtual screening were employed t...

Characterization of volatile flavour compounds and characteristic flavour precursors in poultry eggs based on multi-omics and machine learning.

Food chemistry
Although egg flavour influences consumer preference and satisfaction, the features governing the flavour profiles have been poorly studied. This study investigated the volatile compounds and lipid profiles of different poultry egg yolks (chicken, duc...

Non-destructive assessment of tissue engineered cartilage maturity using visible and near infrared spectroscopy combined with machine learning.

Biosensors & bioelectronics
Tissue engineering is a promising approach to address the unmet clinical need for treating cartilage damage. Monitoring the characteristics of tissue-engineered cartilage constructs (TECs) during culture is critical for optimizing culture conditions ...

Modeling Higher-Order Interactions in Sparse and Heavy-Tailed Neural Population Activity.

Neural computation
Neurons process sensory stimuli efficiently, showing sparse yet highly variable ensemble spiking activity involving structured higher-order interactions. Notably, while neural populations are mostly silent, they occasionally exhibit highly synchronou...