AIMC Topic: Antineoplastic Agents
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Integrative modeling of multi-omics data to identify cancer drivers and infer patient-specific gene activity.
BMC systems biology
Feb 11, 2016
BACKGROUND: High throughput technologies have been used to profile genes in multiple different dimensions, such as genetic variation, copy number, gene and protein expression, epigenetics, metabolomics. Computational analyses often treat these differ...
Drug repositioning for non-small cell lung cancer by using machine learning algorithms and topological graph theory.
BMC bioinformatics
Jan 11, 2016
BACKGROUND: Non-small cell lung cancer (NSCLC) is one of the leading causes of death globally, and research into NSCLC has been accumulating steadily over several years. Drug repositioning is the current trend in the pharmaceutical industry for ident...
Preparation, Characterization, and Antitumor Activities of Miriplatin-Loaded Liposomes.
Journal of pharmaceutical sciences
Dec 22, 2015
Because of the insolubility of miriplatin in water, miriplatin and lipiodol suspension is the sole formulation of miriplatin approved in Japan to treat hepatocellular carcinoma by transcatheter arterial chemoembolization. Until now, there have been n...
Imatinib Increases Serum Creatinine by Inhibiting Its Tubular Secretion in a Reversible Fashion in Chronic Myeloid Leukemia.
Clinical lymphoma, myeloma & leukemia
Dec 20, 2015
BACKGROUND: Monitoring renal function is important in imatinib-treated patients with chronic myeloid leukemia because serum creatinine may increase during the course of therapy. The mechanism of this increase and its reversibility on treatment cessat...
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Imatinib Mesylate
Protein Kinase Inhibitors
Kidney Tubules
Aged
Glomerular Filtration Rate
Humans
Middle Aged
Young Adult
Kidney Function Tests
Retrospective Studies
Antineoplastic Agents
Adult
Creatinine
Case-Control Studies
Female
Drug Substitution
Male
Treatment Outcome
Predicting target proteins for drug candidate compounds based on drug-induced gene expression data in a chemical structure-independent manner.
BMC medical genomics
Dec 18, 2015
BACKGROUND: Phenotype-based high-throughput screening is a useful technique for identifying drug candidate compounds that have a desired phenotype. However, the molecular mechanisms of the hit compounds remain unknown, and substantial effort is requi...
Adjuvant Carboplatin Treatment in 115 Patients With Stage I Seminoma: Retrospective Multicenter Survey.
Clinical genitourinary cancer
Dec 17, 2015
BACKGROUND: The administration of carboplatin AUC 7 has become a standard adjuvant option for patients undergoing orchiectomy for stage I seminoma, in alternative to radiotherapy on retroperitoneal lymphnodes or surveillance. The toxicity of AUC 7 ca...
canSAR: an updated cancer research and drug discovery knowledgebase.
Nucleic acids research
Dec 15, 2015
canSAR (http://cansar.icr.ac.uk) is a publicly available, multidisciplinary, cancer-focused knowledgebase developed to support cancer translational research and drug discovery. canSAR integrates genomic, protein, pharmacological, drug and chemical da...
tcTKB: an integrated cardiovascular toxicity knowledge base for targeted cancer drugs.
AMIA ... Annual Symposium proceedings. AMIA Symposium
Nov 5, 2015
Targeted cancer drugs are often associated with unexpectedly high cardiovascular (CV) adverse events. Systematic approaches to studying CV events associated with targeted anticancer drugs have high potential for elucidating the complex pathways under...
A Tool for Predicting Regulatory Approval After Phase II Testing of New Oncology Compounds.
Clinical pharmacology and therapeutics
Sep 24, 2015
We developed an algorithm (ANDI) for predicting regulatory marketing approval for new cancer drugs after phase II testing has been conducted, with the objective of providing a tool to improve drug portfolio decision-making. We examined 98 oncology dr...
Genomic signatures for paclitaxel and gemcitabine resistance in breast cancer derived by machine learning.
Molecular oncology
Aug 22, 2015
Increasingly, the effectiveness of adjuvant chemotherapy agents for breast cancer has been related to changes in the genomic profile of tumors. We investigated correspondence between growth inhibitory concentrations of paclitaxel and gemcitabine (GI5...
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