AIMC Topic: Antineoplastic Agents
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Machine-Learning Approach for Modeling Myelosuppression Attributed to Nimustine Hydrochloride.
JCO clinical cancer informatics
Dec 1, 2018
PURPOSE: A major adverse effect arising from nimustine hydrochloride (ACNU) therapy for brain tumors is myelosuppression. Because its timing and severity vary among individual patients, the ACNU dose level has been adjusted in an empiric manner at in...
Learning with multiple pairwise kernels for drug bioactivity prediction.
Bioinformatics (Oxford, England)
Jul 1, 2018
MOTIVATION: Many inference problems in bioinformatics, including drug bioactivity prediction, can be formulated as pairwise learning problems, in which one is interested in making predictions for pairs of objects, e.g. drugs and their targets. Kernel...
Implementation and evaluation of a sterile compounding robot in a satellite oncology pharmacy.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
Jun 1, 2018
PURPOSE: The purpose of this study was to quantify the impact of robotic technology on efficiency, accuracy, and cost in a satellite oncology pharmacy.
Detecting Chemotherapeutic Skin Adverse Reactions in Social Health Networks Using Deep Learning.
JAMA oncology
Apr 1, 2018
This study reports proof-of-principle early detection of chemotherapeutic-associated skin adverse drug reactions from social health networks using a deep learning–based signal generation pipeline to capture how patients describe cutaneous eruptions.
Antiproliferative and Apoptotic Activities of the Medicinal Mushroom Phellinus rimosus (Agaricomycetes) on HCT116 Human Colorectal Carcinoma Cells.
International journal of medicinal mushrooms
Jan 1, 2018
Phellinus rimosus is a host-specific wood-rotting polypore that has been reported to be used by some tribes in Kerala, India, for curing mumps. We isolated a novel polysaccharide-protein complex from Ph. rimosus (PPC-Pr) that possessed significant an...
Potential Anticancer Activity of the Parasol Mushroom, Macrolepiota procera (Agaricomycetes), against the A549 Human Lung Cancer Cell Line.
International journal of medicinal mushrooms
Jan 1, 2018
Mushrooms comprise an unlimited source of active compounds that have beneficial health effects without known negative side effects and can potentially be used as important therapeutic products against cancer, which is the leading cause of death world...
Overview of the Biological Activities of a Methanol Extract from Wild Red Belt Conk, Fomitopsis pinicola (Agaricomycetes), Fruiting Bodies from Central Italy.
International journal of medicinal mushrooms
Jan 1, 2018
Fomitopsis pinicola (Sw.) P. Karst. (Fomitopsidaceae) is a medicinal mushroom with a variety of healthy properties. In this study we tested the radical scavenging activity and antimicrobial and anticancer potential of methanol extracts of F. pinicola...
Free Radical Scavengers
Antineoplastic Agents
Fruiting Bodies, Fungal
Phylogeny
Biphenyl Compounds
Coriolaceae
Antifungal Agents
Picrates
Microbial Sensitivity Tests
HT29 Cells
Methanol
Chemical Fractionation
Cell Proliferation
Agaricales
Apoptosis
Humans
THP-1 Cells
Cell Survival
Flavonoids
Phenols
Machine Learning Enables Live Label-Free Phenotypic Screening in Three Dimensions.
Assay and drug development technologies
Jan 1, 2018
There is a large amount of information in brightfield images that was previously inaccessible by using traditional microscopy techniques. This information can now be exploited by using machine-learning approaches for both image segmentation and the c...
Microwave-assisted One-pot Efficient Synthesis of Functionalized 2-Oxo-2-phenylethylidenes-linked 2-Oxobenzo[1,4]oxazines and 2-Oxoquino[1,4]oxalines: Synthetic Applications, Antioxidant Activity, SAR and Cytotoxic Studies.
Acta chimica Slovenica
Dec 1, 2017
A microwave-assisted, environmentally benign green protocol for the synthesis of functionalized (Z)-3-(2-oxo-2-phenylethylidene)-3, 4-dihydro-2H-benzo[b][1,4]oxazin-2-ones (11a-n) in excellent yields (upto 97%) and (Z)-3-(2-oxo-2-phenylethylidene)-3,...
Effects of treatment with chemotherapy and/or tamoxifen on the biomarkers of cardiac injury and oxidative stress in women with breast cancer.
Medicine
Nov 1, 2017
There has been an increase in deaths from cardiovascular diseases following breast cancer therapy. Evidence has shown that this outcome is, in part, associated with cardiotoxicity induced by the chemotherapeutic drugs and the increase in oxidative st...
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