AIMC Topic: Bacterial Infections

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Rapid identification of pathogenic bacteria using Raman spectroscopy and deep learning.

Nature communications Oct 30, 2019
Raman optical spectroscopy promises label-free bacterial detection, identification, and antibiotic susceptibility testing in a single step. However, achieving clinically relevant speeds and accuracies remains challenging due to weak Raman signal from...
Staphylococcus aureus Methicillin-Resistant Staphylococcus aureus Candida Bacterial Infections Logistic Models Spectrum Analysis, Raman Support Vector Machine Escherichia coli Enterococcus Streptococcus Humans Bacterial Typing Techniques Neural Networks, Computer Proteus mirabilis Anti-Bacterial Agents Principal Component Analysis Pseudomonas aeruginosa Deep Learning Salmonella enterica Microbial Sensitivity Tests Klebsiella Single-Cell Analysis Bacteria
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Evaluation of parameters affecting performance and reliability of machine learning-based antibiotic susceptibility testing from whole genome sequencing data.

PLoS computational biology Sep 3, 2019
Prediction of antibiotic resistance phenotypes from whole genome sequencing data by machine learning methods has been proposed as a promising platform for the development of sequence-based diagnostics. However, there has been no systematic evaluation...
Humans Machine Learning Algorithms Genome, Bacterial Computational Biology Anti-Bacterial Agents Databases, Genetic Reproducibility of Results Bacterial Infections Microbial Sensitivity Tests Whole Genome Sequencing Bacteria
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Comparison of the Abbott Architect BRAHMS and the Biomérieux Vidas BRAHMS Procalcitonin Assays.

The journal of applied laboratory medicine Sep 19, 2018
BACKGROUND: Procalcitonin (PCT) is a well-established marker for bacterial infection. Recently the US Food and Drug Administration approved the expanded use of this biomarker to guide clinical decisions for antibiotic treatment in patients with lower...
Luminescent Measurements Immunoassay Sepsis Respiratory Tract Infections Humans Procalcitonin Antimicrobial Stewardship Anti-Bacterial Agents Bacterial Infections Biomarkers Limit of Detection Clinical Decision-Making
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FT-IR Hyperspectral Imaging and Artificial Neural Network Analysis for Identification of Pathogenic Bacteria.

Analytical chemistry Jul 11, 2018
Identification of microorganisms by Fourier transform infrared (FT-IR) spectroscopy is known as a promising alternative to conventional identification techniques in clinical, food, and environmental microbiology. In this study we demonstrate the appl...
Bacterial Typing Techniques Humans Neural Networks, Computer Bacteria Spectroscopy, Fourier Transform Infrared Bacterial Infections
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Using preference learning for detecting inconsistencies in clinical practice guidelines: Methods and application to antibiotherapy.

Artificial intelligence in medicine Jul 9, 2018
Clinical practice guidelines provide evidence-based recommendations. However, many problems are reported, such as contradictions and inconsistencies. For example, guidelines recommend sulfamethoxazole/trimethoprim in child sinusitis, but they also st...
Anti-Bacterial Agents Primary Health Care Decision Support Systems, Clinical Guideline Adherence Humans Machine Learning Decision Support Techniques Practice Patterns, Physicians' Bacterial Infections Knowledge Bases Data Mining Practice Guidelines as Topic
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An ontology-driven clinical decision support system (IDDAP) for infectious disease diagnosis and antibiotic prescription.

Artificial intelligence in medicine Feb 9, 2018
BACKGROUND: The available antibiotic decision-making systems were developed from a physician's perspective. However, because infectious diseases are common, many patients desire access to knowledge via a search engine. Although the use of antibiotics...
Biological Ontologies Drug Prescriptions Drug Therapy, Computer-Assisted ROC Curve Decision Support Systems, Clinical Bacterial Infections Predictive Value of Tests Clinical Decision-Making Reproducibility of Results Diagnosis, Computer-Assisted User-Computer Interface Humans Machine Learning Decision Support Techniques Anti-Bacterial Agents
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Procalcitonin as Predictor of Bacterial Infection in Meconium Aspiration Syndrome.

American journal of perinatology Dec 29, 2017
BACKGROUND: There is a lack of definite consensus on indications for initiating antibiotics in neonates with meconium aspiration syndrome (MAS), instigating researchers to search for a biomarker that can help differentiate MAS from MAS with bacterial...
Procalcitonin Bacterial Infections C-Reactive Protein Leukocyte Count Sensitivity and Specificity Male Humans Meconium Aspiration Syndrome ROC Curve Biomarkers Neutrophils Female Infant, Newborn
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Defining lower airway bacterial infection in children with chronic endobronchial disorders.

Pediatric pulmonology Dec 19, 2017
BACKGROUND: Differentiating lower airway bacterial infection from possible upper airway contamination in children with endobronchial disorders undergoing bronchoalveolar lavage (BAL) is important for guiding management. A diagnostic bacterial load th...
Bronchoalveolar Lavage Bronchial Diseases Cystic Fibrosis Bacterial Load Bronchoalveolar Lavage Fluid Leukocyte Count Neutrophils Male Bronchoscopy Infant Chronic Disease Child, Preschool Bacterial Infections Child Humans Anti-Bacterial Agents Female
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PaPrBaG: A machine learning approach for the detection of novel pathogens from NGS data.

Scientific reports Jan 4, 2017
The reliable detection of novel bacterial pathogens from next-generation sequencing data is a key challenge for microbial diagnostics. Current computational tools usually rely on sequence similarity and often fail to detect novel species when closely...
Computational Biology Sequence Analysis, DNA Humans Bacterial Infections High-Throughput Nucleotide Sequencing Machine Learning Bacteria
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THE BIOLOGICAL ACTIVITIES OF L.

African journal of traditional, complementary, and alternative medicines : AJTCAM Nov 23, 2016
BACKGROUND: Mastitis reduces milk yield and alters milk composition. Antibiotics are widely used in the treatment of the disease. However, this widespread use of antibiotics causes both antibiotic residues in milks and antibiotic resistance developed...
Anti-Bacterial Agents Female Animals Cattle Bacteria Antioxidants Mastitis, Bovine Plant Extracts Bacterial Infections Hypericum Flowers
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