AIMC Topic: Biocompatible Materials

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Controlled surface morphology and hydrophilicity of polycaprolactone toward human retinal pigment epithelium cells.

Materials science & engineering. C, Materials for biological applications
Applying scaffolds as a bed to enhance cell proliferation and even differentiation is one of the treatment of retina diseases such as age-related macular degeneration (AMD) which deteriorating photoreceptors and finally happening blindness. In this s...

A novel 4-DOF surgical instrument with modular joints and 6-Axis Force sensing capability.

The international journal of medical robotics + computer assisted surgery : MRCAS
BACKGROUND: It is difficult for surgeons to exert appropriate forces during delicate operations due to lack of force feedback in robot-assisted minimally invasive surgery (RMIS). A 4-DOF surgical grasper with a modular wrist and 6-axis force sensing ...

Design of a Coupled Thermoresponsive Hydrogel and Robotic System for Postinfarct Biomaterial Injection Therapy.

The Annals of thoracic surgery
BACKGROUND: In preclinical testing, ventricular wall injection of hydrogels has been shown to be effective in modulating ventricular remodeling and preserving cardiac function. For some approaches, early-stage clinical trials are under way. The hydro...

[Extracellular matrix materials and tissue regeneration and repair].

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
The extracellular matrix (ECM) plays a pivotal role in regulating cellular behavior and driving tissue regeneration. Its unique structural characteristics and bioactivity not only provide physical support for cell growth, but also orchestrate tissue ...

Optimal structural characteristics of osteoinductivity in bioceramics derived from a novel high-throughput screening plus machine learning approach.

Biomaterials
Osteoinduction is an important feature of the next generation of bone repair materials. But the key structural factors and parameters of osteoinductive scaffolds are not yet clarified. This study leverages the efficiency of high-throughput screening ...

Identification and Classification of Functional Split G-Quadruplexes Using Machine Learning-Guided Activity Screening.

ACS applied bio materials
Split G-quadruplexes are considered excellent tools for biosensing and diagnostics, but splitting G-quadruplexes may often lead to a loss of function, limiting their effectiveness. This study aims to identify and classify functional split G-quadruple...

Nanotechnology-Enhanced siRNA Delivery: Revolutionizing Cancer Therapy.

ACS applied bio materials
RNA interference (RNAi) has emerged as a transformative approach for cancer therapy, enabling precise gene silencing through small interfering RNA (siRNA). However, the clinical application of siRNA-based treatments faces challenges such as rapid deg...

Beyond 3D Printing: How AI is Shaping the Future of Craniomaxillofacial Bone Tissue Engineering.

ACS biomaterials science & engineering
This perspective focuses on the potential of artificial intelligence (AI) in craniomaxillofacial (CMF) bone tissue engineering, mitigating current challenges, and driving the development of tailored biomaterials and clinical translation. CMF bone tis...

Comparative analysis of deep learning models for predicting biocompatibility in tissue scaffold images.

Computers in biology and medicine
MOTIVATION: Bioprinting enables the creation of complex tissue scaffolds, which are vital for tissue engineering. However, predicting scaffold biocompatibility before fabrication remains a critical challenge, potentially leading to inefficiencies and...

Biomolecular Actuators for Soft Robots.

Chemical reviews
Biomolecules present promising stimuli-responsive mechanisms to revolutionize soft actuators. Proteins, peptides, and nucleic acids foster specific intermolecular interactions, and their boundless sequence design spaces encode precise actuation capab...