BACKGROUND: Microsatellite instability (MSI) has emerged as a predictive biomarker for immunotherapy response in various cancers, but its role in non-small cell lung cancer (NSCLC) is not fully understood.
BACKGROUND: Accurate diagnosis of neuroendocrine neoplasms (NENs) is challenging, especially in poorly differentiated neuroendocrine carcinomas (NECs). This study was aimed to search the best or best combination of neuroendocrine markers in the diagn...
Telomere-related genes (TRGs) are vital in diverse tumor types. Nevertheless, there is a notable lack of in-depth research concerning their significance in head and neck squamous cell carcinoma (HNSCC). In this context, the present study aims to asse...
Artificial intelligence (AI) is increasingly being utilized in cancer research as a computational strategy for analyzing multiomics datasets. Advances in single-cell and spatial profiling technologies have contributed significantly to our understandi...
Clinical cancer research : an official journal of the American Association for Cancer Research
Apr 14, 2025
PURPOSE: A multimodal artificial intelligence (MMAI) biomarker was developed using clinical trial data from North American men with localized prostate cancer treated with definitive radiation, using biopsy digital pathology images and key clinical in...
Studies in health technology and informatics
Apr 8, 2025
Non-specific clinical biomarkers have been shown to help identify prognostic risks in cancer patients. However, the accuracy of prognostic biomarkers for predicting survival in patients with metastatic castration-resistant prostate cancer (mCRPC) sti...
BACKGROUND: Glucose metabolism plays a critical role in the development and progression of kidney renal clear cell carcinoma (KIRC). This study aimed to identify glucose metabolism-related biomarkers (GRBs) and therapeutic targets for KIRC diagnosis ...
Immunotherapy has revolutionized the diagnosis and treatment model for patients with advanced non-small cell lung cancer (NSCLC). Numerous clinical trials and real-world reports have confirmed that PD-L1 status is a key factor for the successful use ...
Journal of cellular and molecular medicine
Apr 1, 2025
TME is a core player in the development of a cancerous lesion, the immune evasive potential of the lesion, and its response to therapy. Sphingolipid metabolism, which governs a number of cellular processes, has been recognised as a player involved in...
RNA biomarkers enable early and precise disease diagnosis, monitoring, and prognosis, facilitating personalized medicine and targeted therapeutic strategies. However, identification of RNA biomarkers is hindered by the challenge of analyzing relative...
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