AIMC Topic: Biomarkers, Tumor
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Identification and single-cell analysis of prognostic genes related to mitochondrial and neutrophil extracellular traps in bladder cancer.
Scientific reports
Jul 4, 2025
The development of bladder cancer (BLCA) is associated with mitochondrial dysfunction and neutrophil extracellular traps (NETs); however, the relationship between mitochondrial function and NET formation in BLCA remains poorly understood. In this stu...
Machine learning combined with multi-omics to identify immune-related LncRNA signature as biomarkers for predicting breast cancer prognosis.
Scientific reports
Jul 4, 2025
This study developed an immune-related long non-coding RNAs (lncRNAs)-based prognostic signature by integrating multi-omics data and machine learning algorithms to predict survival and therapeutic responses in breast cancer patients. Utilizing transc...
Multi-omics analysis identifies SNP-associated immune-related signatures by integrating Mendelian randomization and machine learning in hepatocellular carcinoma.
Scientific reports
Jul 4, 2025
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death globally, characterized by high morbidity and poor prognosis. The complex molecular and immune landscape of HCC makes accurate patient stratification and personalized treatment...
Leveraging pathological markers of lower grade glioma to predict the occurrence of secondary epilepsy, a retrospective study.
Scientific reports
Jul 4, 2025
Epilepsy is a common manifestation in patients with lower grade glioma (LGG), often presenting as the initial symptom in approximately 70% of cases. This study aimed to identify clinical and pathological markers for epileptic seizures in patients wit...
Multiomic integration reveals subtype-specific predictors of neoadjuvant treatment response in breast cancer.
Science advances
Jul 4, 2025
Neoadjuvant therapy has been widely used in breast cancer, but treatment response varies among individuals. We conducted multiomic profiling on tumor samples from 149 Chinese patients with breast cancer across ERHER2, ERHER2, and ERHER2 subtypes, cat...
Machine learning-assisted multi-dimensional transcriptomic analysis of cytoskeleton-related molecules and their relationship with prognosis in hepatocellular carcinoma.
Scientific reports
Jul 3, 2025
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, with a poor prognosis due to its aggressive nature and limited treatment options. Cytoskeletal dynamics play a critical role in tumor progression, but the prognostic...
Simultaneous determination of 7 thiols associated proteins in lymphoma patients'serum and cerebrospinal fluid by UHPLC-HRMS technique.
Scientific reports
Jul 3, 2025
Thiol compounds can serve as markers for the antioxidant and prognostic status of lymphoma, playing a crucial role in early tumor diagnosis. However, their high polarity and lack of chromophores pose challenges for multivariate analysis. This study a...
Fluorescence Guided Raman Spectroscopy enables the training of robust support vector machines for the detection of tumour marker proteins.
Scientific reports
Jul 3, 2025
Raman spectroscopy provides comprehensive biochemical information on a sample's composition, yet it is often used to analyze aggregated spectra rather than specific shifts. We introduce Fluorescence Guided Raman Spectroscopy (FGRS) as a methodology e...
A review of the use of tumour DNA methylation for breast cancer subtyping and prediction of outcomes.
Clinical epigenetics
Jul 2, 2025
DNA methylation in breast tumours has been extensively studied and has provided valuable insights into the clinical heterogeneity of breast cancer. In this review, we summarise the current literature that has used DNA methylation markers to subtype b...
Cohesive data analysis for the identification of prognostic hub genes and significant pathways associated with HER2 + and TN breast cancer types.
Scientific reports
Jul 2, 2025
Breast cancer is the most prevalent and lethal form of cancer being the utmost common medical concern of women. Breast cancer etiology implicates numerous cellular protein receptors such as estrogen receptors (ER), progesterone receptors (PR), and hu...
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