Mitochondrial autophagy (mitophagy) in macrophages is crucial yet poorly understood within the lung adenocarcinoma (LUAD) tumor microenvironment. This study aimed to identify key macrophage mitophagy-related genes and develop a robust prognostic mode...
Homologous recombination deficiency (HRD) is a critical biomarker for guiding targeted therapies, yet the full range of somatic alterations driving HRD across cancers remains incompletely characterized. Here, we present a tumor-agnostic machine learn...
Cholangiocarcinoma is a very deadly epithelial cell cancer with poor clinical outcome. Cellular senescence plays a vital role in the oncogenesis and the aggressiveness of cholangiocarcinoma. Integrative machine learning procedure including 10 methods...
Endometrial carcinoma (EC) has demonstrated a concerning epidemiological trajectory. Current evaluation systems for EC are limited to postoperative analysis, necessitating the development of a preoperative risk stratification model. Researchers aimed...
Accurate prognostication is essential to guide clinical management in localised cutaneous melanoma (CM), the form of skin cancer with the highest mortality. While the tumour microenvironment (TME) plays a key role in disease progression, current stag...
Cancer immunology, immunotherapy : CII
Nov 18, 2025
Immunohistochemistry (IHC) remains the gold standard for evaluating protein expression in tumor microenvironment analysis. This approach hinders robust correlation analyses between spatial heterogeneity in the tumor microenvironment and clinical outc...
This study examines the function of chromatin-remodeling genes (CRGs) in nasopharyngeal carcinoma (NPC), with an emphasis on their potential as prognostic and diagnostic biomarkers. We examined gene expression information collected from multiple data...
BACKGROUND: Accurate quantification of the Ki-67 proliferation index is essential for breast cancer prognosis and treatment planning. Current automated methods, including classical and deep learning approaches based on cell detection or segmentation,...
Pyroptosis is a newly discovered form of programmed cell death, but its mechanism in the development of cervical cancer has not been elucidated. Cervical cancer differentially expressed pyroptosis-related genes were identified via bioinformatic analy...
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) presents a significant challenge, with a 5-year survival rate of approximately 10%. Tumor heterogeneity contributes to the limited effectiveness of treatments. Several tumor and stroma molecular cla...
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