AIMC Topic: Biomarkers, Tumor
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Rapid diagnosis of TERT promoter mutation using Terahertz absorption spectroscopy in glioblastoma.
Scientific reports
May 27, 2025
Glioblastoma (GBM) is a highly aggressive brain tumor with poor outcomes and limited treatment options. The telomerase reverse transcriptase (TERT) promoter mutation, one of the key biomarkers in GBM, is linked to tumor progression and prognosis. Thi...
Machine learning-based diagnostic and prognostic models for breast cancer: a new frontier on the clinical application of natural killer cell-related gene signatures in precision medicine.
Frontiers in immunology
May 27, 2025
BACKGROUND: Breast cancer (BC) remains a leading cause of cancer-related mortality among women worldwide. Natural killer (NK) cells play a crucial role in the innate immune system and exhibit significant anti-tumor activity. However, the role of NK c...
Identification and validation of prognostic genes associated with T-cell exhaustion and macrophage polarization in breast cancer.
Frontiers in endocrinology
May 27, 2025
BACKGROUND: The most frequent malignant tumor in women is breast cancer (BRCA). It has been discovered that T-cell exhaustion and macrophages play significant roles in BRCA. It was necessary to explore prognostic genes associated with T-cell exhausti...
Identification of a novel chemotherapy benefit index for patients with advanced ovarian cancer based on Bayesian network analysis.
PloS one
May 27, 2025
BACKGROUND: This study aims to evaluate the efficacy of chemotherapy and optimize treatment strategies for patients with advanced ovarian cancer.
Development of AI-integrated smartphone sponge-based sensors utilizing His@Co-NC nanozymes for highly sensitive sarcosine detection.
Biosensors & bioelectronics
May 26, 2025
The increasing demand for point-of-care detection of low-concentration cancer biomarkers has necessitated the development of innovative nanozyme-based sensing technologies. Here, a smartphone-integrated platform is presented that utilizes artificial ...
Multiomics in Renal Cell Carcinoma: Current Landscape and Future Directions for Precision Medicine.
Current urology reports
May 26, 2025
PURPOSE OF REVIEW: Renal cell carcinoma (RCC) is a prevalent and increasingly diagnosed malignancy associated with high mortality and recurrence rates. Traditional diagnostic and therapeutic approaches have limitations due to the disease's molecular ...
The development of predictive biomarkers and immunologic markers for breast cancer: current status and future perspectives.
Brazilian journal of biology = Revista brasleira de biologia
May 26, 2025
Breast cancer is the leading cause of cancer-related mortality among women worldwide. The development of predictive biomarkers and immunologic markers has revolutionized breast cancer diagnosis and treatment, enabling personalized medicine approaches...
Liquid Biopsy: The Challenges of a Revolutionary Approach in Oncology.
International journal of molecular sciences
May 23, 2025
Liquid biopsy has gained attention in oncology as a non-invasive diagnostic tool, offering valuable insights into tumor biology through the analysis of circulating nucleic acid (cfDNA and cfRNA), circulating tumor cells (CTCs), extracellular vesicles...
Single-cell multimodal analysis reveals tumor microenvironment predictive of treatment response in non-small cell lung cancer.
Science advances
May 23, 2025
Non-small cell lung cancer (NSCLC) constitutes over 80% of lung cancer cases and remains a leading cause of cancer-related mortality worldwide. Despite the advent of immune checkpoint inhibitors, their efficacy is limited to 27 to 45% of patients. Id...
Innate immune cell barrier-related genes inform precision prognosis in pancreatic cancer.
Frontiers in immunology
May 23, 2025
INTRODUCTION: Pancreatic cancer (PC) remains a lethal malignancy with limited treatment options. The role of innate immune cell barrier-related genes in PC prognosis is poorly defined. This study aimed to identify prognostic biomarkers, develop a pre...
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