AIMC Topic: Biomarkers
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Integrating machine learning and neural networks for new diagnostic approaches to idiopathic pulmonary fibrosis and immune infiltration research.
PloS one
Apr 24, 2025
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease with a fatal outcome, known for its rapid progression and unpredictable clinical course. However, the tools available for diagnosing and treating IPF are quite limited. T...
Feasibility of human ethomic biomarkers for the diagnosis and monitoring of hip osteoarthritis.
Journal of biomechanics
Apr 23, 2025
Radiographic imaging is typically used to diagnose osteoarthritis (OA). However, patients would typically be sent for imaging after they present to a physician because of joint pain. By this time, the condition is likely irreversible. This study aims...
Challenges and Opportunities: Nanomaterials in Epilepsy Diagnosis.
ACS nano
Apr 23, 2025
Epilepsy is a common neurological disorder characterized by a significant rate of disability. Accurate early diagnosis and precise localization of the epileptogenic zone are essential for timely intervention, seizure prevention, and personalized trea...
Vascular-related biological stress, DNA methylation, allostatic load and domain-specific cognition: an integrated machine learning and causal inference approach.
BMC neurology
Apr 23, 2025
BACKGROUND: Vascular disease in aging populations spans a wide range of disorders including strokes, circulation disorders and hypertension. As individuals age, vascular disorders co-occur and hence exert combined effects. In the present study we int...
Integrating WGCNA and SVM-RFE identifies hub molecular biomarkers driving ischemic stroke progression.
Neurological research
Apr 22, 2025
BACKGROUND: Stroke is the second most common cause of death worldwide and the leading cause of long-term severe disability with neurological impairment worsening within hours after stroke onset and being especially involved with motor function. So fa...
Cerebrospinal fluid inflammatory cytokines as prognostic indicators for cognitive decline across Alzheimer's disease spectrum.
Journal of Alzheimer's disease : JAD
Apr 22, 2025
BackgroundNeuroinflammation actively contributes to the pathophysiology of Alzheimer's disease (AD); however, the value of neuroinflammatory biomarkers for disease-staging or predicting disease progression remains unclear.ObjectiveTo investigate diag...
Explainable machine learning framework for biomarker discovery by combining biological age and frailty prediction.
Scientific reports
Apr 22, 2025
Biological age (BA) and frailty represent two distinct health measures that offer valuable insights into the aging process. Comparing and analyzing blood-based biomarkers from the machine learning (ML) predictors of BA and frailty helps deepen our un...
Advancing osteoarthritis research: the role of AI in clinical, imaging and omics fields.
Bone research
Apr 22, 2025
Osteoarthritis (OA) is a degenerative joint disease with significant clinical and societal impact. Traditional diagnostic methods, including subjective clinical assessments and imaging techniques such as X-rays and MRIs, are often limited in their ab...
Updates on novel and traditional OCT and OCTA biomarkers in nAMD.
Eye (London, England)
Apr 19, 2025
Predictivity of optical coherence tomography (OCT) examination for the development of neovascular age-related macular degeneration (nAMD) was demonstrated to be superior compared to other methods, suggesting it as an elective method for screening pur...
Diagnostic MicroRNA Signatures to Support Classification of Pulmonary Hypertension.
Circulation. Genomic and precision medicine
Apr 18, 2025
BACKGROUND: Patients with pulmonary hypertension (PH) are classified based on disease pathogenesis and hemodynamic drivers. Classification informs treatment. The heart failure biomarker NT-proBNP (N-terminal pro-B-type natriuretic peptide) is used to...
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