OBJECTIVES: Retinal diseases, major causes of vision impairment and blindness, are assessed using optical coherence tomography (OCT) scans. Automated report generation for retinal OCT scans, powered by deep learning, can help standardize interpretati...
Platelets are increasingly recognized as key players not only in hemostasis, but also in immunity and inflammation. However, the mechanisms and markers underlying their activation remain incompletely understood. This study aimed to decipher how plate...
BACKGROUND: Osteoarthritis (OA) is a common degenerative disorder characterized primarily by articular cartilage degradation and chronic inflammation. Although direct evidence elucidating the specific mechanisms underlying the coagulation-immune axis...
BACKGROUND: Obesity is a disease with high heterogeneity. Both overall obesity and central obesity are associated with increased risks of having cardio-metabolic co-morbidities. This study is aimed to examine the cardio-metabolic characteristics and ...
Hepatitis B virus-related acute-on-chronic liver failure (ACHBLF) is a severe condition associated with short-term mortality without liver transplantation. Substantial evidence indicates that necroptosis and immune infiltration play critical roles in...
Lyme neuroborreliosis (LNB), a nervous system infection caused by tick-borne spirochetes of the Borrelia burgdorferi sensu lato complex, is among the most frequent bacterial infections of the nervous system in Europe. Early diagnosis and continuous m...
BACKGROUND: Dengue shock syndrome (DSS), with critical complications encompassing mechanical ventilation (MV), dengue-associated acute liver failure (PALF), and encephalitis, is associated with high mortality in children. Although serum lactate is a ...
BACKGROUND: Preeclampsia (PE) is a multisystem disorder characterized primarily by hypertension and proteinuria after 20 weeks of gestation, significantly impacting maternal and fetal health. The etiology remains unclear, but it is primarily attribut...
Biochemical and biophysical research communications
Oct 24, 2025
BACKGROUND: Aortic valve stenosis with coronary artery disease (AS-CAD) represents a common yet complex cardiovascular comorbidity, characterized by multifactorial pathogenesis and a lack of specific serum biomarkers. These limitations hinder early d...
Simultaneous detection of metabolites and proteins─two chemically and functionally distinct classes of biomolecules─in complex biofluids remains a significant analytical hurdle, yet is critical for early and accurate disease diagnosis. These difficul...
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