BACKGROUND: There is still no clinical biomarker to diagnose depression. Given the complexity of a multifactorial disease like depression, a single biomarker is unlikely to capture the full heterogeneity of the disease and be applicable in clinical p...
Atrial fibrillation (AF), the most prevalent critical care arrhythmia, demonstrates substantial mortality associations where renal dysfunction management plays a pivotal therapeutic role. We examined the prognostic capacity of admission blood urea ni...
Our study explores signatures for Crohn's disease (CD) and Ulcerative Colitis (UC) reflecting an interplay between the intestinal microbiota, systemic inflammation, and plasma bile acid homeostasis. For this, 1,257 individuals scheduled for colonosco...
Chronic kidney disease (CKD) can induce chronic heart failure (CHF), a condition referred to as type 4 cardiorenal syndrome (CRS4). The pathophysiological mechanisms remain unclear, and suitable early warning biomarkers for CHF in CKD patients are la...
BACKGROUND: Vascular mild cognitive impairment (VMCI) is a significant global health concern, particularly in Asia. The visual cognitive assessment test (VCAT) has shown promise as a language-neutral screening tool for cognitive impairment.
Early diagnosis of Alzheimer's disease (AD) requires blood biomarker tests sensitive to femtogram/mL concentrations. Graphene field-effect transistors (GFETs) are promising for this application, but suffer from device-to-device variability and requir...
The diagnosis of asymptomatic tuberculosis (TB) remains challenging due to an early disease stage. This study aimed to identify and validate plasma biomarkers for asymptomatic TB by integrating the Olink proteomics with multiple machine learning algo...
BACKGROUND AND AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease worldwide. Progression from simple metabolic dysfunction-associated steatotic liver (MASL) without necro-inflammation to...
BACKGROUND: The diagnostic and therapeutic potential of neutrophil extracellular traps (NETs) in liver fibrosis (LF) has not been fully explored. We aim to screen and verify NETs-related liver fibrosis biomarkers through machine learning.
Accurate differentiation of schizophrenia (SZ) and bipolar disorder (BD) is crucial for effective clinical management. However, current diagnostic methods, which rely heavily on subjective assessments, are prone to high rates of misdiagnosis. This st...
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