Clinical pharmacology in drug development
Jan 26, 2015
PURPOSE: Rucaparib is a potent Poly (ADP-ribose) Polymerase (PARP) inhibitor currently under clinical development. The objectives of this analysis were to establish population PK and PK/PD models for rucaparib, and to evaluate the predictability of P...
Nonsteroidal anti-inflammatory drugs are the most used anti-inflammatory medicines in the world. Side effects still occur, however, and some inflammatory pathologies lack efficient treatment. Cyclooxygenase and lipoxygenase pathways are of utmost imp...
BACKGROUND: Investigations into novel biomarkers using omics techniques generate large amounts of data. Due to their size and numbers of attributes, these data are suitable for analysis with machine learning methods. A key component of typical machin...
Mild cognitive impairment (MCI) is a transitional stage between age-related cognitive decline and Alzheimer's disease (AD). For the effective treatment of AD, it would be important to identify MCI patients at high risk for conversion to AD. In this s...
Cephalalgia : an international journal of headache
Sep 16, 2014
BACKGROUND: Mathematical modeling approaches are becoming ever more established in clinical neuroscience. They provide insight that is key to understanding complex interactions of network phenomena, in general, and interactions within the migraine-ge...
BACKGROUND AND OBJECTIVE: The importance of data standards when integrating clinical research data has been recognized. The common data element (CDE) is a consensus-based data element for data harmonization and sharing between clinical researchers, i...
Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disorder that has serious physical and mental health implications. It is evident that disruptions to mitochondrial function have a considerable impact on the survival, activation, and di...
Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the therapeutic landscape for relapsed or refractory lymphoid malignancies, achieving remarkable rates of durable remission. Despite this success, significant variability among patient...
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Dec 15, 2025
Intracerebral hemorrhage (ICH) is a major cause of death and disability worldwide. Despite treatment advances, reliable prognostic biomarkers are still lacking. While phagocytosis regulation is implicated in ICH pathogenesis, its potential for diagno...
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Dec 15, 2025
Cryptogenic stroke represents 25%-40% of ischemic strokes, with many cases harboring unrecognized large artery atherosclerosis (LAA) requiring specific secondary prevention. In this multicenter pilot study, we developed a metabolomics-based machine l...
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