Niemann-Pick type C (NPC) disease is a devastating, fatal, neurodegenerative disease and a form of lysosomal storage disorder. It is caused by mutations in either NPC1 or NPC2 genes, leading to the accumulation of cholesterol and other lipids in the ...
BACKGROUND: Depressive symptoms are highly prevalent in first-episode psychosis (FEP) and worsen clinical outcomes. It is currently difficult to determine which patients will have persistent depressive symptoms based on a clinical assessment. We aime...
BACKGROUND: The variability in treatment response in people with rheumatoid arthritis (RA) warrants the prediction of patients at high risk of treatment failure. Identification of biomarkers linked to clinical remission in RA is currently a challenge...
Journal of pharmaceutical and biomedical analysis
Jul 25, 2025
Primary Sjögren's Syndrome (pSS) is a complex autoimmune disease with an unclear etiology. Due to the lack of a single diagnostic gold standard, multidisciplinary and invasive examinations are often required for pSS, underscoring the urgent need for ...
Consumer-driven blueberry quality improvement requires a deeper understanding of how metabolic composition influences sensory perception. This study integrates untargeted metabolomics and machine learning to identify biomarker metabolites shaping sen...
BACKGROUND: Ultra-early detection of brain injury biomarkers within the critical first hour post-injury remains a major clinical challenge in mild traumatic brain injury (mTBI) management. Conventional platforms (e.g., ELISA) suffer from limited sens...
Psychological resilience is influenced by both psychological and biological factors. However, the potential of using DNA methylation (DNAm) probes and brain imaging variables to predict psychological resilience remains unclear. This study aimed to in...
This cross-sectional investigation seeks to examine the association between dietary omega-3 fatty acids (including α-linolenic acid [ALA], eicosapentaenoic acid [EPA], and docosahexaenoic acid [DHA]) and biomarkers of cellular aging, specifically DNA...
Intrahepatic cholestasis of pregnancy is the most common pregnancy-related liver disease, manifesting typically during the third trimester of pregnancy with pruritus and elevated serum bile acids. This condition is associated with increased fetal mor...
Although pesticide application is indispensable for agricultural productivity, improper use can pose significant health risks, particularly for vulnerable populations. This study investigated the effects of pesticide exposure on metabolic pathways an...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.