Rapid and label-free evaluation of induced pluripotent stem cell (iPSC) pluripotency is critical for advancing regenerative medicine and clinical applications. Although traditional genomics- and proteomics-based pluripotency assessment methods are re...
Neurofilament light chain (NfL), a cytoskeletal protein released during neuronal injury, is a promising biomarker, with elevated levels consistently associated with disease severity and progression in multiple neurological conditions, including Alzhe...
Biochemical and biophysical research communications
Nov 11, 2025
Osteoarthritis (OA) is the most common degenerative joint disease, and the complexity of its molecular mechanisms has hindered the development of effective diagnostic and therapeutic strategies. In this study, we integrated five independent OA RNA-se...
Developing a sensitive analytical platform for monitoring tiopronin (MPG), its metabolite 2-mercaptopropionic acid (MPA), and the key liver biomarker glutathione (GSH) is crucial for liver health assessment. Here, an artificial intelligence-assisted ...
Diabetes mellitus (DM), a prevalent metabolic disorder, poses significant diagnostic and therapeutic challenges, especially, in the early stage diagnosis of diabetes related complications. Accurate early stage diagnosis of diabetes and its complicati...
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the interplay of genetic and environmental factors, and currently, there there is a lack of effective diagnostic or therapeutic strategies available...
BACKGROUND: Atrial fibrillation (AF) is a major cardiovascular issue in critically ill patients, linked to elevated mortality rates. The Stress Hyperglycemia Ratio (SHR), a novel metric of glucose control, has shown promise in predicting adverse outc...
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by a wide spectrum of motor and non-motor symptoms, often leading to delayed or inaccurate diagnosis. Conventional diagnostic methods frequently suffer from limited se...
Regulatory T cells are a class of T lymphocytes which respond to activation signals by expanding their cell numbers, and whose culturing and expansion are of significant clinical interest. Cellular activation states are used to inform process control...
: Analysis of small molecule metabolites found in blood plasma of patients undergoing treatment for STEMI has the potential to be used as a clinical diagnostic and prognostic tool, capable of predicting disease progression, risk of negative outcomes,...
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