AIMC Topic: Biomarkers
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Discovering Novel Biomarkers and Potential Therapeutic Targets of Amyotrophic Lateral Sclerosis Through Integrated Machine Learning and Gene Expression Profiling.
Journal of molecular neuroscience : MN
Apr 30, 2025
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that has multiple factors that make its molecular pathogenesis difficult to understand and its diagnosis and treatment during the early stages difficult to determine. Dis...
Explainable Machine Learning Model for Predicting Persistent Sepsis-Associated Acute Kidney Injury: Development and Validation Study.
Journal of medical Internet research
Apr 28, 2025
BACKGROUND: Persistent sepsis-associated acute kidney injury (SA-AKI) shows poor clinical outcomes and remains a therapeutic challenge for clinicians. Early identification and prediction of persistent SA-AKI are crucial.
Biological age prediction in schizophrenia using brain MRI, gut microbiome and blood data.
Brain research bulletin
Apr 27, 2025
The study of biological age prediction using various biological data has been widely explored. However, single biological data may offer limited insights into the pathological process of aging and diseases. Here we evaluated the performance of machin...
Machine learning-based prediction of bleeding risk in extracorporeal membrane oxygenation patients using transfusion as a surrogate marker.
Transfusion
Apr 25, 2025
BACKGROUND: The increasing use of extracorporeal membrane oxygenation (ECMO) has highlighted challenges in managing bleeding complications. Optimal transfusion strategies remain uncertain for this diverse patient group, necessitating accurate predict...
Identifying disease progression biomarkers in metabolic associated steatotic liver disease (MASLD) through weighted gene co-expression network analysis and machine learning.
Journal of translational medicine
Apr 24, 2025
BACKGROUND: Metabolic Associated Steatotic Liver Disease (MASLD), encompassing conditions simple liver steatosis (MAFL) and metabolic associated steatohepatitis (MASH), is the most prevalent chronic liver disease. Currently, the management of MASLD i...
Identification and verification of mitochondria-related genes biomarkers associated with immune infiltration for COPD using WGCNA and machine learning algorithms.
Scientific reports
Apr 24, 2025
Mitochondrial dysfunction plays a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD). This study combines bioinformatics analysis with machine learning to elucidate potential key mitochondrial-related genes associated wi...
Integrating machine learning and neural networks for new diagnostic approaches to idiopathic pulmonary fibrosis and immune infiltration research.
PloS one
Apr 24, 2025
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease with a fatal outcome, known for its rapid progression and unpredictable clinical course. However, the tools available for diagnosing and treating IPF are quite limited. T...
Feasibility of human ethomic biomarkers for the diagnosis and monitoring of hip osteoarthritis.
Journal of biomechanics
Apr 23, 2025
Radiographic imaging is typically used to diagnose osteoarthritis (OA). However, patients would typically be sent for imaging after they present to a physician because of joint pain. By this time, the condition is likely irreversible. This study aims...
Challenges and Opportunities: Nanomaterials in Epilepsy Diagnosis.
ACS nano
Apr 23, 2025
Epilepsy is a common neurological disorder characterized by a significant rate of disability. Accurate early diagnosis and precise localization of the epileptogenic zone are essential for timely intervention, seizure prevention, and personalized trea...
Vascular-related biological stress, DNA methylation, allostatic load and domain-specific cognition: an integrated machine learning and causal inference approach.
BMC neurology
Apr 23, 2025
BACKGROUND: Vascular disease in aging populations spans a wide range of disorders including strokes, circulation disorders and hypertension. As individuals age, vascular disorders co-occur and hence exert combined effects. In the present study we int...
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