OBJECTIVES: Spingosine-1-phosphate (S1P) and ceramides are bioactive sphingolipids that influence cancer cell fate. Anti-ceramide antibodies might inhibit the effects of ceramide. The aim of this study was to assess the potential role of circulating ...
OBJECTIVES: The pairing of immunotherapy and radiotherapy in the treatment of locally advanced nonsmall cell lung cancer (NSCLC) has shown promise. By combining radiotherapy with immunotherapy, the synergistic effects of these modalities not only bol...
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
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Multiple instance learning(MIL) has shown superior performance in the classification of whole-slide images(WSIs). The implementation of multiple instance learning for WSI classification typically involves two components, i.e., a feature extractor, wh...
AIM: To develop and validate a machine learning (ML) model based on positron emission tomography/computed tomography (PET/CT) multi-modality fusion radiomics to improve the prediction efficiency of mediastinal-hilar lymph node metastasis (LNM).
AI decision support systems can assist clinicians in planning adaptive treatment strategies that can dynamically react to individuals' cancer progression for effective personalized care. However, AI's imperfections can lead to suboptimal therapeutics...
The rapid development of artificial intelligence (AI) based tools in pathology laboratories has brought forward unlimited opportunities for pathologists. Promising AI applications used for accomplishing diagnostic, prognostic and predictive tasks are...
Classification of adenocarcinoma (AC) and squamous cell carcinoma (SCC) poses significant challenges for cytopathologists, often necessitating clinical tests and biopsies that delay treatment initiation. To address this, we developed a machine learni...
This study aims to apply a multi-modal approach of the deep learning method for survival prediction in patients with non-small-cell lung cancer (NSCLC) using CT-based radiomics. We utilized two public data sets from the Cancer Imaging Archive (TCIA) ...
PURPOSE: To comprehensively analyze the association between preoperative maximum standardized uptake value (SUV) on 18F-fluorodeoxyglucose positron emission tomography-computed tomography and postoperative recurrence in resected non-small cell lung c...
BACKGROUND: Immune checkpoint inhibitors (CPIs) have revolutionized cancer therapy for several tumor indications. However, a substantial fraction of patients treated with CPIs derive no benefit or have short-lived responses to CPI therapy. Identifyin...