AIMC Topic: Case-Control Studies

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Serum lipid metabolic characteristics and potential biomarkers in first-episode schizophrenia.

BMC psychiatry
BACKGROUND: Lipids play a vital role in health and disease, but changes to their circulating levels and the link with schizophrenia remains poorly characterized. This study aimed to investigate the pathological lipid profiles in patients with first-e...

Cell-free DNA methylation and fragmentomics-based liquid biopsy for accurate esophageal cancer detection.

BMC cancer
BACKGROUND: Cell-free DNA is a promising source of biomarkers for early cancer detection and carries tumor-driven methylation and fragmentation features that have achieved good diagnostic efficacy across various cancers. However, there were no studie...

Classifying schizophrenia subtypes via resting-state EEG complexity networks.

Scientific reports
Schizophrenia (SZ) is increasingly recognized as a network disorder marked by abnormal functional connectivity, yet the clinical utility of fMRI remains limited. Electroencephalography (EEG) provides a more practical alternative, though conventional ...

Functional connectivity between non-motor and motor networks predicts motor recovery changes after stroke.

Scientific reports
Stroke impairs limb motor function, which affects patients' quality of life and imposes economic burdens. Early prediction of motor recovery is essential for guiding treatment and rehabilitation. While the corticospinal tract is a known biomarker, th...

Plasma metabolomics disentangles T2DM- and CAD-specific dysmetabolism and identifies potential biomarkers for CAD risk escalation in diabetic patients.

Cardiovascular diabetology
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major driver of coronary artery disease (CAD). Prior studies often conflate T2DM- and CAD-specific metabolic alterations, limiting insights into CAD pathogenesis in T2DM. This study aimed to distinguis...

Association between gut microbiota composition and physical functioning in patients with knee osteoarthritis: a machine learning study.

Scientific reports
Gut dysbiosis and systemic inflammation are increasingly recognized in the pathogenesis of knee osteoarthritis (OA). While altered gut microbiota profiles have been reported, the link between specific microbial taxa and physical functioning in OA pat...

Pilot case control evaluation of artificial intelligence assisted orthodontic monitoring and pediatric patient perception.

Scientific reports
Artificial Intelligence (AI) has become a key tool in the modernization of the healthcare industry, aiding dentists in performing their work more efficiently and effectively. The aim of this study was to evaluate orthodontic monitoring and patient pe...

Identify MRI negative temporal lobe epilepsy with resting fMRI indicators and machine learning techniques.

Scientific reports
About 30% of temporal lobe epilepsy (TLE) cases are negative on MRI, so quantitative diagnosis based on clinical symptoms becomes challenging. There is an urgent need for an accurate and reliable method to differentiate patients with MRI-negative TLE...

Precision integrated identification of predictive first-trimester metabolomics signatures for early detection of gestational diabetes mellitus.

Cardiovascular diabetology
BACKGROUND AND AIM: Gestational diabetes mellitus (GDM), a common pregnancy-related metabolic disorder, often goes undiagnosed until the second trimester, limiting early intervention opportunities. Given the higher prevalence of GDM in India, there i...

Prediction of uterine cavity conception environment using two-dimensional transvaginal ultrasound imaging semantic feature-based machine learning: a case-control study.

BMC pregnancy and childbirth
BACKGROUND: Independently investigating the association between pregnancy outcomes and the uterine cavity conception environment (UCCE) is challenging. Therefore, this study aimed to employ a range of machine learning algorithms to systematically ana...