AIMC Topic: Cell Line, Tumor

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Chemical characterization and wound healing property of a β-D-glucan from edible mushroom Piptoporus betulinus.

International journal of biological macromolecules Dec 20, 2017
A water-soluble β-D-glucan was obtained from fruiting bodies of Piptoporus betulinus, by hot aqueous extraction followed by freeze-thawing procedure and dialysis. Its molar mass distribution and conformational behavior in solution was assessed by siz...
Humans Cell Line, Tumor Wound Healing Cell Movement Magnetic Resonance Spectroscopy Cell Line Glucans Agaricales Gas Chromatography-Mass Spectrometry Monosaccharides
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Machine Learning for Nuclear Mechano-Morphometric Biomarkers in Cancer Diagnosis.

Scientific reports Dec 20, 2017
Current cancer diagnosis employs various nuclear morphometric measures. While these have allowed accurate late-stage prognosis, early diagnosis is still a major challenge. Recent evidence highlights the importance of alterations in mechanical propert...
Humans Cell Line, Tumor Image Interpretation, Computer-Assisted Cell Nucleus Optical Imaging Neural Networks, Computer Biomarkers, Tumor Neoplasms Deep Learning
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Physicochemical characterization and in vitro hypoglycemic activities of polysaccharides from Sargassum pallidum by microwave-assisted aqueous two-phase extraction.

International journal of biological macromolecules Dec 19, 2017
Microwave-assisted aqueous two-phase extraction (MAATPE) was applied for simultaneous extraction and separation of polysaccharides from Sargassum pallidum (SPPs). The optimal extraction parameters, physicochemical properties, and hypoglycemic activit...
Molecular Conformation Glycoside Hydrolase Inhibitors Amylases Sargassum Spectroscopy, Fourier Transform Infrared Humans Models, Molecular Cell Line, Tumor Polysaccharides Hypoglycemic Agents Liquid-Liquid Extraction Monosaccharides Molecular Weight Microscopy, Atomic Force Chemical Phenomena Microwaves alpha-Glucosidases
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Two new bis-iridoids isolated from Scabiosa stellata and their antibacterial, antioxidant, anti-tyrosinase and cytotoxic activities.

Fitoterapia Dec 19, 2017
This study presents the chemical profile investigation of a 70% ethanol extract obtained from Scabiosa stellata, a medicinal herbaceous traditionally used to treat heel cracks. A C NMR-based dereplication methodology was firstly applied on centrifuga...
Molecular Structure Monophenol Monooxygenase Enterococcus faecalis Iridoids Dipsacaceae Staphylococcus epidermidis Humans Anti-Bacterial Agents Cell Line, Tumor Antioxidants Plant Extracts
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5-fluorouracil combined with cisplatin and mitomycin C as an optimized regimen for hyperthermic intraperitoneal chemotherapy in gastric cancer.

Journal of surgical oncology Dec 19, 2017
BACKGROUND AND OBJECTIVES: Optimized drug regimens for hyperthermic intraperitoneal chemotherapy (HIPEC) have not been standardized completely in patients with advanced gastric cancer (GC). We evaluated an optimized anti-tumor protocol comprising 5-f...
Fluorouracil Mitomycin Hyperthermia, Induced Cell Growth Processes Antineoplastic Combined Chemotherapy Protocols Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Cisplatin Humans Stomach Neoplasms Cell Line, Tumor
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The Interplay Between Epithelial-Mesenchymal Transition (EMT) and the Thyroid Hormones-αvβ3 Axis in Ovarian Cancer.

Hormones & cancer Dec 19, 2017
Ovarian cancer is a highly metastatic disease. The metastatic potential is enhanced by epithelial to mesenchymal transition (EMT) in which αvβ3 integrin plays a role. Thyroid hormones (L-thyroxine, T4, and 3,5,3'-triiodo-L-thyronine, T3) bind this in...
Humans Thyroid Hormones Vimentin Ovarian Neoplasms Integrin alphaVbeta3 Zonula Occludens-1 Protein Female Triiodothyronine Snail Family Transcription Factors Epithelial-Mesenchymal Transition beta Catenin Cell Line, Tumor Zinc Finger E-box-Binding Homeobox 1 Thyroxine Gene Expression Regulation, Neoplastic Cadherins Signal Transduction
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Effect of dacarbazine on CD44 in live melanoma cells as measured by atomic force microscopy-based nanoscopy.

International journal of nanomedicine Dec 18, 2017
CD44 ligand-receptor interactions are known to be involved in regulating cell migration and tumor cell metastasis. High expression levels of CD44 correlate with a poor prognosis of melanoma patients. In order to understand not only the mechanistic ba...
Microscopy, Atomic Force Actins Hyaluronan Receptors Tubulin Single Molecule Imaging Mice Cell Survival Quantum Dots Melanoma Kinetics Animals Dacarbazine Cell Line, Tumor
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Evaluation of Aristolochia indica L. and Piper nigrum L. methanol extract against centipede Scolopendra moristans L. using Wistar albino rats and screening of bioactive compounds by high pressure liquid chromatography: a polyherbal formulation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Nov 28, 2017
The present study was aimed to explore the anti-venom activity of Aristolochia indica and Piper nigrum plants against the centipede (Scolopendra moristans) envenomation in animal model. In vtiro phytochemical, antioxidant and blocking of proteolysis ...
Venoms Phytochemicals Organ Specificity Phytotherapy Methanol Piper nigrum Chromatography, High Pressure Liquid Mice Proteolysis Behavior, Animal Humans Antioxidants Toxicity Tests, Acute Plant Extracts Animals Annelida Rats, Wistar Antineoplastic Agents Antivenins Lipids Cell Line, Tumor Aristolochia Electrolytes
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From word models to executable models of signaling networks using automated assembly.

Molecular systems biology Nov 24, 2017
Word models (natural language descriptions of molecular mechanisms) are a common currency in spoken and written communication in biomedicine but are of limited use in predicting the behavior of complex biological networks. We present an approach to b...
Antineoplastic Agents Cell Line, Tumor Gene Expression Regulation, Neoplastic Models, Genetic Drug Resistance, Neoplasm Humans Signal Transduction Tumor Suppressor Protein p53 Neural Networks, Computer Computer Simulation Proto-Oncogene Proteins p21(ras) Natural Language Processing Language Proto-Oncogene Proteins B-raf DNA Damage Melanoma Vemurafenib Sulfonamides Skin Neoplasms Indoles Enzyme Inhibitors
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Selective cytotoxic and genotoxic activities of 5-(2-bromo-5-methoxybenzylidene)-thiazolidine-2,4-dione against NCI-H292 human lung carcinoma cells.

Pharmacological reports : PR Nov 22, 2017
BACKGROUND: Thiazolidine-2,4-dione ring system is used as a pharmacophore to build various heterocyclic compounds aimed to interact with biological targets. In the present study, benzylidene-2,4-thiazolidinedione derivatives (compounds 2-5) were synt...
Thiazolidinediones Humans Leukocytes, Mononuclear Antineoplastic Agents Cell Line, Tumor Cytotoxins Comet Assay Lung Neoplasms Mutagens Apoptosis HL-60 Cells MCF-7 Cells K562 Cells DNA Fragmentation
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