AIMC Topic: Cell Line, Tumor

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[Study of FN1 and ZNF438 gene expression negatively regulated by androgen receptor in androgen-independent LNCaP cells].

Zhonghua yi xue za zhi Dec 19, 2015
OBJECTIVE: To verify whether FN1 and ZNF438 are the androgen receptor(AR) target genes in LNCaP-AI cells and investigate the effects of AR exerts on FN1 and ZNF438 gene expression.
Male Oligonucleotide Array Sequence Analysis Gene Expression Regulation, Neoplastic Humans Gene Expression Repressor Proteins Cell Line, Tumor Blotting, Western RNA, Messenger Androgens Prostatic Neoplasms Dihydrotestosterone Fibronectins Down-Regulation Receptors, Androgen
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[Enhanced radiosensitivity of H22 ascitic tumor to 12C6+ ions radiation in ultra-filtration extract mixture from Astragalus mongholicus-treated mice].

Yao xue xue bao = Acta pharmaceutica Sinica Dec 1, 2015
This study was designed to investigate the impact of ultra-filtration extract mixture from Astragals mongholicus (UEMAM) o radiosensitivity of H22 ascitic tumor in mice to 12C6+ ions radiation. The H22 ascitic tumor model was established in mice by i...
DNA Damage Radiation Tolerance Ions Animals Cell Cycle Astragalus Plant Cell Line, Tumor Neoplasms, Experimental Plant Extracts Mice Signal Transduction Apoptosis
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A systematic approach to prioritize drug targets using machine learning, a molecular descriptor-based classification model, and high-throughput screening of plant derived molecules: a case study in oral cancer.

Molecular bioSystems Dec 1, 2015
Systems-biology inspired identification of drug targets and machine learning-based screening of small molecules which modulate their activity have the potential to revolutionize modern drug discovery by complementing conventional methods. To utilize ...
Machine Learning Protein Binding Drug Discovery Computational Biology High-Throughput Screening Assays Humans Cell Line, Tumor ROC Curve Molecular Conformation Gene Expression Regulation, Neoplastic Gene Regulatory Networks Antineoplastic Agents, Phytogenic Receptors, CXCR4 Binding Sites Models, Molecular Protein Interaction Mapping Mouth Neoplasms
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LncRNA ontology: inferring lncRNA functions based on chromatin states and expression patterns.

Oncotarget Nov 24, 2015
Accumulating evidences suggest that long non-coding RNAs (lncRNAs) perform important functions. Genome-wide chromatin-states area rich source of information about cellular state, yielding insights beyond what is typically obtained by transcriptome pr...
Humans Algorithms Cells, Cultured Neoplasms RNA, Messenger Models, Genetic Hep G2 Cells Cell Line Gene Expression Profiling Cell Line, Tumor Gene Regulatory Networks Histones Gene Ontology Chromatin Transcription Initiation Site RNA, Long Noncoding HeLa Cells Methylation Promoter Regions, Genetic Lysine K562 Cells
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[Feasibility Study for Storage and Re-Utilization of Circulating Tumor Cells (CTCs)].

Rinsho byori. The Japanese journal of clinical pathology Oct 1, 2015
BACKGROUND: In this era of precision medicine, monitoring patients requires not only real time but also longitudinal sequence of samples at various time points. Based on this background, we focused on conditioned circumstances on fixation and storage...
In Situ Hybridization, Fluorescence Specimen Handling Neoplastic Cells, Circulating Humans Feasibility Studies Cytological Techniques Cell Line, Tumor Lung Neoplasms
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[Sensitization of human colon cancer HT-29 cells to TRAIL-induced apoptosis by gambognic acid].

Yao xue xue bao = Acta pharmaceutica Sinica Oct 1, 2015
To investigate the effects of gambognic acid (GA) on TRAIL-induced apoptosis of cancer cells, human colon HT-29 cancer cells were treated with GA to promote apoptosis. Inhibition of the cell proliferation was measured with MTT assay and cell apoptosi...
Humans Apoptosis Reactive Oxygen Species Cell Line, Tumor Cell Proliferation TNF-Related Apoptosis-Inducing Ligand Colonic Neoplasms Down-Regulation HT29 Cells Xanthones Up-Regulation Apoptosis Regulatory Proteins Caspases
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A multi-stage random forest classifier for phase contrast cell segmentation.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference Jan 1, 2015
We present a machine learning based approach to automatically detect and segment cells in phase contrast images. The proposed method consists of a multi-stage classification scheme based on random forest (RF) classifier. Both low level and mid level ...
Humans Machine Learning Image Processing, Computer-Assisted Artifacts Cluster Analysis Signal-To-Noise Ratio Algorithms Cell Line, Tumor Microscopy, Phase-Contrast
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Untethered magnetic millirobot for targeted drug delivery.

Biomedical microdevices Jan 1, 2015
This paper reports the design and development of a novel millimeter-sized robotic system for targeted therapy. The proposed medical robot is conceived to perform therapy in relatively small diameter body canals (spine, urinary system, ovary, etc.), a...
Lab-On-A-Chip Devices Equipment Failure Analysis Infusion Pumps, Implantable Robotics Equipment Design Doxorubicin Magnets Magnetic Fields Miniaturization Delayed-Action Preparations Humans Cell Line, Tumor Urinary Bladder Neoplasms
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