AIMC Topic: Cell Line
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Learn to segment single cells with deep distance estimator and deep cell detector.
Computers in biology and medicine
Apr 8, 2019
Single cell segmentation is a critical and challenging step in cell imaging analysis. Traditional processing methods require time and labor to manually fine-tune parameters and lack parameter transferability between different situations. Recently, de...
Automatic localization and identification of mitochondria in cellular electron cryo-tomography using faster-RCNN.
BMC bioinformatics
Mar 29, 2019
BACKGROUND: Cryo-electron tomography (cryo-ET) enables the 3D visualization of cellular organization in near-native state which plays important roles in the field of structural cell biology. However, due to the low signal-to-noise ratio (SNR), large ...
Convolutional neural network for cell classification using microscope images of intracellular actin networks.
PloS one
Mar 13, 2019
Automated cell classification is an important yet a challenging computer vision task with significant benefits to biomedicine. In recent years, there have been several studies attempted to build an artificial intelligence-based cell classifier using ...
Cytoplasm
Cytoskeleton
Breast
Automation
Pattern Recognition, Automated
Actins
Reproducibility of Results
Breast Neoplasms
Cell Line, Tumor
Image Processing, Computer-Assisted
Cell Line
Models, Statistical
MCF-7 Cells
Microscopy, Fluorescence
Neural Networks, Computer
Machine Learning
Algorithms
Female
Humans
Discovery of small molecule binders of human FSHR(TMD) with novel structural scaffolds by integrating structural bioinformatics and machine learning algorithms.
Journal of molecular graphics & modelling
Mar 5, 2019
BACKGROUND: The activation of follicle stimulating hormone receptor (FSHR) by FSH and the consequent downstream signaling activities are crucial for reproductive health. The role of FSHR in tumor progression as well as osteoporosis advancement has al...
Exploration of the nanomedicine-design space with high-throughput screening and machine learning.
Nature biomedical engineering
Feb 18, 2019
Only a tiny fraction of the nanomedicine-design space has been explored, owing to the structural complexity of nanomedicines and the lack of relevant high-throughput synthesis and analysis methods. Here, we report a methodology for determining struct...
Whey Protein Complexes with Green Tea Polyphenols: Antimicrobial, Osteoblast-Stimulatory, and Antioxidant Activities.
Cells, tissues, organs
Jan 24, 2019
Polyphenols are known for their antimicrobial activity, whilst both polyphenols and the globular protein β-lactoglobulin (bLG) are suggested to have antioxidant properties and promote cell proliferation. These are potentially useful properties for a ...
Near-infrared mito-specific fluorescent probe for ratiometric detection and imaging of alkaline phosphatase activity with high sensitivity.
Journal of materials chemistry. B
Dec 19, 2018
Fluorescent probe-based analytical methods for biological species have gained increasing attention for their powerful detection and imaging capabilities. However, it is still occasionally problematic for accurate analyses due to the influence of the ...
Functional expression of porcine interferon-α using a combinational strategy in Pichia pastoris GS115.
Enzyme and microbial technology
Dec 10, 2018
Porcine interferon-α (pIFN-α) could be used as the vaccine adjuvant to enhance the antiviral ability of porcine in swine industry. In here, a combinational strategy integrating codon optimization, multiple gene insertion, strong AOX1 promoter, and ef...
Protective effect of polysaccharide from Sophora japonica L. flower buds against UVB radiation in a human keratinocyte cell line (HaCaT cells).
Journal of photochemistry and photobiology. B, Biology
Dec 5, 2018
Natured botanical extract has attracted considerable attention recently in the field of skin anti-ultraviolet (UV) radiation. As a medicinal herb, Sophora japonica flower buds contained several components such as flavonoids, isoflavonoids, triterpene...
Smart Plasmonic Nanorobot for Real-Time Monitoring Cytochrome c Release and Cell Acidification in Apoptosis during Electrostimulation.
Analytical chemistry
Dec 4, 2018
Cytochrome c (Cyt c) release and cellular pH change are two important mediators of apoptosis. Effective methods to regulate or monitor such two events are therefore highly desired for apoptosis research and cancer cell therapy. Herein, we exploited e...
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