AIMC Topic: Cell Movement
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A data-driven approach to establishing cell motility patterns as predictors of macrophage subtypes and their relation to cell morphology.
PloS one
Dec 31, 2024
The motility of macrophages in response to microenvironment stimuli is a hallmark of innate immunity, where macrophages play pro-inflammatory or pro-reparatory roles depending on their activation status during wound healing. Cell size and shape have ...
Integration of Graph Neural Networks and multi-omics analysis identify the predictive factor and key gene for immunotherapy response and prognosis of bladder cancer.
Journal of translational medicine
Dec 23, 2024
OBJECTIVE: The evaluation of the efficacy of immunotherapy is of great value for the clinical treatment of bladder cancer. Graph Neural Networks (GNNs), pathway analysis and multi-omics analysis have shown great potential in the field of cancer diagn...
Cell Movement
Apoptosis
Proteasome Endopeptidase Complex
Prognosis
Gene Expression Regulation, Neoplastic
Cell Proliferation
Reproducibility of Results
Treatment Outcome
Tumor Microenvironment
Urinary Bladder Neoplasms
Cell Line, Tumor
Single-Cell Analysis
Computational Biology
Immunotherapy
Multiomics
Humans
Neural Networks, Computer
CXCL12 impact on glioblastoma cells behaviors under dynamic culture conditions: Insights for developing new therapeutic approaches.
PloS one
Dec 23, 2024
Glioblastoma multiforme (GBM) is the most prevalent malignant brain tumor, with an average survival time of 14 to 20 months. Its capacity to invade brain parenchyma leads to the failure of conventional treatments and subsequent tumor recurrence. Rece...
Effects of aqueous and ethanolic extracts of Chinese propolis on dental pulp stem cell viability, migration and cytokine expression.
PeerJ
Dec 18, 2024
BACKGROUND: Propolis is a natural substance produced by honeybees that has various biological properties including, anti-inflammatory, antioxidant and antimicrobial properties. Although previous studies have evaluated the antimicrobial effects of pro...
A programmable, open-source robot that scratches cultured tissues to investigate cell migration, healing, and tissue sculpting.
Cell reports methods
Dec 9, 2024
Despite the widespread popularity of the "scratch assay," where a pipette is dragged manually through cultured tissue to create a gap to study cell migration and healing, it carries significant drawbacks. Its heavy reliance on manual technique can co...
Deep learning reveals a damage signalling hierarchy that coordinates different cell behaviours driving wound re-epithelialisation.
Development (Cambridge, England)
Sep 24, 2024
One of the key tissue movements driving closure of a wound is re-epithelialisation. Earlier wound healing studies describe the dynamic cell behaviours that contribute to wound re-epithelialisation, including cell division, cell shape changes and cell...
Impact of Mitophagy-Related Genes on the Diagnosis and Development of Esophageal Squamous Cell Carcinoma via Single-Cell RNA-seq Analysis and Machine Learning Algorithms.
Journal of microbiology and biotechnology
Sep 23, 2024
As a treatment for esophageal squamous cell carcinoma (ESCC), which is common and fatal, mitophagy is a conserved cellular mechanism that selectively removes damaged mitochondria and is crucial for cellular homeostasis. While tumor development and re...
Apoptosis Regulatory Proteins
Mitochondrial Proteins
Mitophagy
RNA-Seq
Single-Cell Gene Expression Analysis
Gene Expression Regulation, Neoplastic
Cell Proliferation
Cell Movement
Esophageal Neoplasms
Mitochondria
Biomarkers, Tumor
Esophageal Squamous Cell Carcinoma
Humans
Transcriptome
Machine Learning
Cell Line, Tumor
Single-Cell Analysis
Algorithms
Prognosis
Forecasting and Predicting Stochastic Agent-Based Model Data with Biologically-Informed Neural Networks.
Bulletin of mathematical biology
Sep 23, 2024
Collective migration is an important component of many biological processes, including wound healing, tumorigenesis, and embryo development. Spatial agent-based models (ABMs) are often used to model collective migration, but it is challenging to thor...
Interpretable Fine-Grained Phenotypes of Subcellular Dynamics via Unsupervised Deep Learning.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Sep 6, 2024
Uncovering fine-grained phenotypes of live cell dynamics is pivotal for a comprehensive understanding of the heterogeneity in healthy and diseased biological processes. However, this endeavor poses significant technical challenges for unsupervised ma...
Collection of microrobots for gentle cell manipulation.
Science robotics
Aug 28, 2024
Optically actuated soft microrobotic tools were designed for cell transportation, manipulation, and cell-to-cell interactions.
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