AIMC Topic: Cell Proliferation
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Role of α-fetoprotein in differentiation of regulatory T lymphocytes.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections
Jan 4, 2018
The effect of native α-fetoprotein (AFP) on the expression of T-regulatory lymphocyte (Treg) markers by activated CD4 lymphocytes with different proliferative status was studied. α-Fetoprotein did not affect the ratio of proliferating and non-prolife...
Effect of bovine lactoferrin and human lactoferrin on the proliferative activity of the osteoblast cell line MC3T3-E1 in vitro.
Journal of dairy science
Dec 28, 2017
We conducted a comparative in vitro study on the proliferative effects of natural human lactoferrin (nhLF) and bovine lactoferrin (bLF) on osteoblasts. We investigated cell proliferation, cell survival, cell cycle, and mRNA and protein expression of ...
Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis.
European journal of medicinal chemistry
Dec 28, 2017
Bruton's tyrosine kinase (Btk) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) and Fcγ receptor (FcR) signaling pathways, which makes it a uniquely attractive target for the treatment of autoimmune diseases, such as rheum...
Mice
Arthritis, Rheumatoid
Rats
Pyrroles
Cell Proliferation
Protein Kinase Inhibitors
Humans
Pyrimidines
Agammaglobulinaemia Tyrosine Kinase
Animals
Haplorhini
Drug Design
Structure-Activity Relationship
Rats, Sprague-Dawley
Models, Molecular
Dose-Response Relationship, Drug
Molecular Structure
Cell Line
Dogs
Protein-Tyrosine Kinases
Microsomes, Liver
Graphene oxide-doping improves the biocompatibility and separation performance of polyethersulfone hollow fiber membranes for bioartificial kidney application.
Journal of colloid and interface science
Dec 27, 2017
HYPOTHESIS: Graphene oxide (GO)-doping in polyethersulfone hollow fiber membranes (PES HFMs) improves the biocompatibility and separation performance for bioartificial kidney (BAK) application.
Human Wharton's Jelly-Derived Stem Cells Display a Distinct Immunomodulatory and Proregenerative Transcriptional Signature Compared to Bone Marrow-Derived Stem Cells.
Stem cells and development
Dec 21, 2017
Mesenchymal stromal cells (MSCs) are multipotent stem cells with immunosuppressive and trophic support functions. While MSCs from different sources frequently display a similar appearance in culture, they often show differences in their surface marke...
Lycopene-rich extract from red guava (Psidium guajava L.) displays cytotoxic effect against human breast adenocarcinoma cell line MCF-7 via an apoptotic-like pathway.
Food research international (Ottawa, Ont.)
Oct 27, 2017
This study investigated a lycopene-rich extract from red guava (LEG) for its chemical composition using spectrophotometry, mass spectrometry, attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR), and computational studies. ...
Effects of salinity on bacterial communities, Maillard reactions, isoflavone composition, antioxidation and antiproliferation in Korean fermented soybean paste (doenjang).
Food chemistry
Oct 26, 2017
The purpose of this study was to investigate bacterial communities and health-benefit-related parameters in doenjang prepared with various brine concentrations (8, 12, 16, and 20%). Phenolic, flavonoid, melanoidin and isoflavone contents, antioxidati...
An Advanced Deep Learning Approach for Ki-67 Stained Hotspot Detection and Proliferation Rate Scoring for Prognostic Evaluation of Breast Cancer.
Scientific reports
Jun 12, 2017
Being a non-histone protein, Ki-67 is one of the essential biomarkers for the immunohistochemical assessment of proliferation rate in breast cancer screening and grading. The Ki-67 signature is always sensitive to radiotherapy and chemotherapy. Due t...
Novel Imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxides as antiproliferative trypanosoma cruzi drugs: Computational screening from neural network, synthesis and in vivo biological properties.
European journal of medicinal chemistry
May 1, 2017
A new family of imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxide with antiproliferative Trypanosoma cruzi properties was identified from a neural network model published by our group. The synthesis and evaluation of this new class of trypanocidal agents ...
Anticancer and anti-inflammatory activities of girinimbine isolated from .
Drug design, development and therapy
Dec 28, 2016
Therapy that directly targets apoptosis and/or inflammation could be highly effective for the treatment of cancer. is an edible herb that has been traditionally used for cancer treatment as well as inflammation. Here, we describe that girinimbine, a...
Nitric Oxide
Cell Proliferation
Apoptosis
Lipopolysaccharides
Humans
Cytokines
Animals
Mice
Structure-Activity Relationship
Anti-Inflammatory Agents, Non-Steroidal
Zebrafish
Alkaloids
HT29 Cells
Dose-Response Relationship, Drug
Cell Survival
Antineoplastic Agents, Phytogenic
Drug Screening Assays, Antitumor
Tumor Cells, Cultured
Murraya
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