AIMC Topic: Cell Proliferation

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Grape Seed Proanthocyanidin Extract Inhibits Human Esophageal Squamous Cancerous Cell Line ECA109 via the NF-B Signaling Pathway.

Mediators of inflammation Dec 17, 2018
Esophageal squamous cell carcinoma is the most common type of squamous cell carcinoma. Grape seed proanthocyanidin extract (GSPE) is considered to exhibit anticancer activity against several different types of cancer. We aimed to determine whether GS...
Esophageal Neoplasms Proanthocyanidins Esophageal Squamous Cell Carcinoma Grape Seed Extract Cell Movement Apoptosis Cell Survival Caspase 3 Humans Cell Line, Tumor NF-kappa B Enzyme-Linked Immunosorbent Assay Cell Proliferation Signal Transduction
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Morphological profiling using machine learning reveals emergent subpopulations of interferon-γ-stimulated mesenchymal stromal cells that predict immunosuppression.

Cytotherapy Nov 28, 2018
BACKGROUND: Although a preponderance of pre-clinical data demonstrates the immunosuppressive potential of mesenchymal stromal cells (MSCs), significant heterogeneity and lack of critical quality attributes (CQAs) based on immunosuppressive capacity l...
Humans Machine Learning Cells, Cultured Leukocytes, Mononuclear Lymphocyte Activation Coculture Techniques Interferon-gamma Stochastic Processes Cell Proliferation Tissue Embedding Cell Plasticity CD8-Positive T-Lymphocytes Immunosuppression Therapy CD4-Positive T-Lymphocytes Mesenchymal Stem Cells
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Isolation and identification of immunomodulatory selenium-containing peptides from selenium-enriched rice protein hydrolysates.

Food chemistry Sep 20, 2018
The RAW264.7 cell model was employed to screen immunomodulatory selenium-containing peptides from selenium-enriched rice protein hydrolysates (SPHs). Moreover, the selenium-containing peptides of high-activity protein hydrolysates were purified by Se...
Mice Nitric Oxide Metalloendopeptidases Cell Proliferation Macrophages Amino Acid Sequence Protein Hydrolysates Oryza Chromatography, High Pressure Liquid Animals Immunologic Factors Selenomethionine Tandem Mass Spectrometry Peptides Sonication RAW 264.7 Cells Selenium
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The antifibrotic effect of isolate tagitinin C from tithonia diversifolia (Hemsley) A. Gray on keloid fibroblast cell.

The Pan African medical journal Aug 8, 2018
INTRODUCTION: Keloids characterized by fibroblast hyperproliferation and depositions of collagen which similar to cancer cells. Tagitinin C is a class of sesquiterpene lactones (SLS) was isolated from the leaves of the moon flower (Hemsley) A. Gray....
Humans Cells, Cultured Time Factors Enzyme-Linked Immunosorbent Assay Cell Proliferation Inhibitory Concentration 50 Fibroblasts Collagen Dose-Response Relationship, Drug Asteraceae Cell Survival Keloid Sesquiterpenes Mitomycin
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Assessment of Functional Phosphatidylinositol 3-Kinase Pathway Activity in Cancer Tissue Using Forkhead Box-O Target Gene Expression in a Knowledge-Based Computational Model.

The American journal of pathology Jul 6, 2018
The phosphatidylinositol 3-kinase (PI3K) pathway is commonly activated in cancer. Tumors are potentially sensitive to PI3K pathway inhibitors, but reliable diagnostic tests that assess functional PI3K activity are lacking. Because PI3K pathway activi...
Phosphatidylinositol 3-Kinases Forkhead Transcription Factors Knowledge Bases Diagnostic Tests, Routine Humans Female Breast Neoplasms Gene Expression Profiling Computational Biology Superoxide Dismutase Cell Proliferation Phosphorylation
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Antiproliferative and anti-apoptotic effect of astaxanthin in an oxygen-induced retinopathy mouse model.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie Apr 11, 2018
OBJECTIVE: To evaluate the impact of intravitreal (IV) and intraperitoneal (IP) astaxanthin (AST) injections on neovascular development (ND), retinal morphology, and apoptotic activity in a C57BL/6J mouse model with hyperoxia-induced retinopathy (HIR...
Retina Animals, Newborn Mice, Inbred BALB C Animals Hyperoxia Apoptosis Mice Xanthophylls Dose-Response Relationship, Drug In Situ Nick-End Labeling Cell Proliferation Random Allocation Fibrinolytic Agents Intravitreal Injections Disease Models, Animal Retinal Diseases Oxygen Microscopy, Electron
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Machine learning prioritizes synthesis of primaquine ureidoamides with high antimalarial activity and attenuated cytotoxicity.

European journal of medicinal chemistry Jan 31, 2018
Primaquine (PQ) is a commonly used drug that can prevent the transmission of Plasmodium falciparum malaria, however toxicity limits its use. We prepared five groups of PQ derivatives: amides 1a-k, ureas 2a-k, semicarbazides 3a,b, acylsemicarbazides 4...
Animals Antineoplastic Agents Rats Cell Proliferation Dose-Response Relationship, Drug Humans Machine Learning Primaquine Plasmodium falciparum Molecular Structure Antimalarials Malaria, Falciparum Erythrocytes Cell Line Amides Drug Screening Assays, Antitumor Structure-Activity Relationship
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Role of α-fetoprotein in differentiation of regulatory T lymphocytes.

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections Jan 4, 2018
The effect of native α-fetoprotein (AFP) on the expression of T-regulatory lymphocyte (Treg) markers by activated CD4 lymphocytes with different proliferative status was studied. α-Fetoprotein did not affect the ratio of proliferating and non-prolife...
alpha-Fetoproteins T-Lymphocytes, Regulatory Humans Cells, Cultured Female Adult Cell Proliferation Cell Differentiation
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Effect of bovine lactoferrin and human lactoferrin on the proliferative activity of the osteoblast cell line MC3T3-E1 in vitro.

Journal of dairy science Dec 28, 2017
We conducted a comparative in vitro study on the proliferative effects of natural human lactoferrin (nhLF) and bovine lactoferrin (bLF) on osteoblasts. We investigated cell proliferation, cell survival, cell cycle, and mRNA and protein expression of ...
RNA, Messenger Cell Proliferation Cell Line Cell Survival Animal Feed Humans Animals Lactoferrin Osteoblasts
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Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis.

European journal of medicinal chemistry Dec 28, 2017
Bruton's tyrosine kinase (Btk) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) and Fcγ receptor (FcR) signaling pathways, which makes it a uniquely attractive target for the treatment of autoimmune diseases, such as rheum...
Agammaglobulinaemia Tyrosine Kinase Haplorhini Pyrroles Molecular Structure Dogs Microsomes, Liver Protein Kinase Inhibitors Pyrimidines Cell Line Protein-Tyrosine Kinases Structure-Activity Relationship Models, Molecular Humans Animals Drug Design Mice Arthritis, Rheumatoid Rats Cell Proliferation Rats, Sprague-Dawley Dose-Response Relationship, Drug
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