AIMC Topic: Cell Proliferation

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NeuroCellCentreDB: Exploring a Novel Dataset for Neuron-like Cell Centre Detection with Deep Neural Networks.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
The manipulation and stimulation of cell growth is invaluable for neuroscience research such as brain-machine interfaces or applications of neural tissue engineering. For the implementation of such research avenues, in particular the analysis of cell...

Identification of novel CDK2 inhibitors by a multistage virtual screening method based on SVM, pharmacophore and docking model.

Journal of enzyme inhibition and medicinal chemistry
Cyclin-dependent kinase 2 (CDK2) is the family of Ser/Thr protein kinases that has emerged as a highly selective with low toxic cancer therapy target. A multistage virtual screening method combined by SVM, protein-ligand interaction fingerprints (PLI...

Investigation of the biochemical and apoptotic changes in breast cancer cells treated with leaf extract from tea (Camellia sinensis L.) grown with added boric acid.

Pakistan journal of pharmaceutical sciences
Tea obtained from the leaves of Camellia sinensis L., a medicinal plant, is a widely popular beverage. Deficiency in boron, a micronutrient for C. sinensis, affects the growth as well as the quality of tea. The aim of this study was to explore whethe...

The anti-ageing effects of a natural peptide discovered by artificial intelligence.

International journal of cosmetic science
OBJECTIVE: As skin ages, impaired extracellular matrix (ECM) protein synthesis and increased action of degradative enzymes manifest as atrophy, wrinkling and laxity. There is mounting evidence for the functional role of exogenous peptides across many...

Current Advances and Limitations of Deep Learning in Anticancer Drug Sensitivity Prediction.

Current topics in medicinal chemistry
Anticancer drug screening can accelerate drug discovery to save the lives of cancer patients, but cancer heterogeneity makes this screening challenging. The prediction of anticancer drug sensitivity is useful for anticancer drug development and the i...

[Inhibiting effect and mechanism of Lactobacillus E6-1 on oral cancer cell line Cal-27].

Shanghai kou qiang yi xue = Shanghai journal of stomatology
PURPOSE: To study the effect of Lactobacillus E6-1 on proliferation and apoptosis of human oral cancer cell line Cal-27 in vitro.

Effects of Jiazhu decoction in combination with cyclophosphamide on breast cancer in mice.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
OBJECTIVE: To investigate the therapeutic effects of Jiazhu decoction (JZD) in combination with cyclophosphamide (CTX) on the growth of breast cancer in mice and to explore the possible molecular mechanisms of action.

Dissecting celastrol with machine learning to unveil dark pharmacology.

Chemical communications (Cambridge, England)
By coalescing bespoke machine learning and bioinformatics analyses with cell-based assays, we unveil the pharmacology of celastrol. Celastrol is a direct modulator of the progesterone and cannabinoid receptors, and its effects correlate with the anti...