AIMC Topic: Cell Survival
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Purification of viable peripheral blood mononuclear cells for biobanking using a robotized liquid handling workstation.
Journal of translational medicine
Nov 12, 2019
BACKGROUND: The purification of peripheral blood mononuclear cells (PBMCs) by means of density gradient (1.07 g/mL) centrifugation is one of the most commonly used methods in diagnostics and research laboratories as well as in biobanks. Here, we eval...
Label-Free Estimation of Therapeutic Efficacy on 3D Cancer Spheres Using Convolutional Neural Network Image Analysis.
Analytical chemistry
Oct 24, 2019
Despite recent advances in cancer treatment, developing better therapeutic reagents remains an essential task for oncologists. To accurately characterize drug efficacy, 3D cell culture holds great promise as opposed to conventional 2D monolayer cultu...
Humans
Neural Networks, Computer
Breast Neoplasms
Image Processing, Computer-Assisted
Optical Imaging
Tumor Cells, Cultured
Antibiotics, Antineoplastic
Microfluidic Analytical Techniques
Drug Screening Assays, Antitumor
Structure-Activity Relationship
Equipment Design
Doxorubicin
Cell Proliferation
Dose-Response Relationship, Drug
Cell Survival
Novel Screening Method Identifies PI3Kα, mTOR, and IGF1R as Key Kinases Regulating Cardiomyocyte Survival.
Journal of the American Heart Association
Oct 16, 2019
Background Small molecule kinase inhibitors (KIs) are a class of agents currently used for treatment of various cancers. Unfortunately, treatment of cancer patients with some of the KIs is associated with cardiotoxicity, and there is an unmet need fo...
Deep learning-assisted literature mining for in vitro radiosensitivity data.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Aug 17, 2019
BACKGROUND AND PURPOSE: Integrated analysis of existing radiosensitivity data obtained by the gold-standard clonogenic assay has the potential to improve our understanding of cancer cell radioresistance. However, extraction of radiosensitivity data f...
Large-Scale Screening of Natural Products Transactivating Peroxisome Proliferator-Activated Receptor α Identifies 9S-Hydroxy-10E,12Z,15Z-Octadecatrienoic Acid and Cymarin as Potential Compounds Capable of Increasing Apolipoprotein A-I Transcription in Human Liver Cells.
Lipids
Feb 1, 2019
Increasing apolipoprotein A-I (apoA-I), the predominant protein of high-density lipoprotein (HDL) particles, has favorable effects on atherogenic risk factors. Here, we investigated the effects of peroxisome proliferator-activated receptor α (PPARα) ...
Neuronal survival of DRG neurons after neurite transection in vitro promotes by nerve growth factor and brain derived neurotrophic factor.
Cellular and molecular biology (Noisy-le-Grand, France)
Dec 31, 2018
Neurotrophic factors are growth factors that promote neuronal survival, regulate synaptic function and neurotransmitter release, and promote the plasticity and growth of axons in the peripheral and central nervous systems. This study focused on the r...
In vitro bioactivity and degradation behaviour of β-wollastonite derived from natural waste.
Materials science & engineering. C, Materials for biological applications
Dec 29, 2018
Calcium silicate ceramics, in particular wollastonite (CaSiO), is the most commonly used bioactive material for bone regeneration and repairing applications. The present study aims to synthesize cost effective wollastonite using natural waste materia...
Photoluminescence-tunable fluorescent carbon dots-deposited silver nanoparticle for detection and killing of bacteria.
Materials science & engineering. C, Materials for biological applications
Dec 22, 2018
Innovative methods to detect and kill pathogenic bacteria have a pivotal role in the eradication of infectious diseases and the prevention of the growth of antibiotic-resistant bacteria. The combination of fluorescent carbon dots (FCDs) with silver n...
Multifunctional luminescent immuno-magnetic nanoparticles: toward fast, efficient, cell-friendly capture and recovery of circulating tumor cells.
Journal of materials chemistry. B
Dec 19, 2018
Highly efficient isolation and recovery of viable circulating tumor cells (CTCs) from the blood of patients is an important precondition to address the current dilemma of insufficient CTC studies, and can promote the development of individualized ant...
Grape Seed Proanthocyanidin Extract Inhibits Human Esophageal Squamous Cancerous Cell Line ECA109 via the NF-B Signaling Pathway.
Mediators of inflammation
Dec 17, 2018
Esophageal squamous cell carcinoma is the most common type of squamous cell carcinoma. Grape seed proanthocyanidin extract (GSPE) is considered to exhibit anticancer activity against several different types of cancer. We aimed to determine whether GS...
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