AIMC Topic: Chromatography, High Pressure Liquid
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Untangling the Postmortem Metabolome: A Machine Learning Approach for Accurate PMI Estimation.
Analytical chemistry
Jul 23, 2025
Accurate estimation of the postmortem interval (PMI) is crucial for medico-legal investigations, providing critical timelines for criminal cases. Current PMI methods, however, often lack precision, limiting their forensic utility. In this study, we d...
Multiclass classification of thalassemia types using complete blood count and HPLC data with machine learning.
Scientific reports
Jul 21, 2025
Mild to severe anemia is caused by thalassemia, a common genetic disorder affecting over 100 countries worldwide, that results from the abnormality of one or several of the four globin genes. This leads to chronic hemolytic anemia and disrupted synth...
Simultaneous determination of 7 thiols associated proteins in lymphoma patients'serum and cerebrospinal fluid by UHPLC-HRMS technique.
Scientific reports
Jul 3, 2025
Thiol compounds can serve as markers for the antioxidant and prognostic status of lymphoma, playing a crucial role in early tumor diagnosis. However, their high polarity and lack of chromophores pose challenges for multivariate analysis. This study a...
Plasma Lyso-PE 22:6 and Lyso-PE 20:4 are associated with development of mild to moderate depression revealed by metabolomics: a pilot study.
BMC psychiatry
Jul 1, 2025
BACKGROUND: Mild to moderate depression (MMD), as an early stage of depression, has a high incidence and may progress to severe depression, even leading to suicide. The lack of effective screening and treatment is due to the unknown metabolic changes...
A novel UHPLC-HRMS method for simultaneous determination of 20 amino metabolites and proteins in lymphoma patients' cells and serum.
Scientific reports
Jul 1, 2025
Highly sensitive and selective monitoring of amino metabolites such as glutamine, arginine, tryptophan and related proteins played significant roles in early diagnosis and warning of lymphoma. But those limited abundance and lacked chromophore group ...
Targeted metabolomics reveals bioactive inflammatory mediators from gut into blood circulation in children with NAFLD.
NPJ biofilms and microbiomes
Jul 1, 2025
Altered gut metabolites are important for the inflammatory progression in children with NAFLD. Fecal and plasma samples were collected from 145 subjects including 53 non-alcoholic fatty liver (NAFL), 39 nonalcoholic steatohepatitis (NASH) and 53 obes...
Study on the quantitative analysis of Tilianin based on Raman spectroscopy combined with deep learning.
PloS one
Jun 18, 2025
Tilianin is a commonly used pharmaceutical ingredient with various biological activities such as antioxidant, anti-inflammatory, and anticancer, which is able to exert antitumor effects by inhibiting tumor cell proliferation, inducing apoptosis and i...
Substrate Specificity of the Organic Cation Transporters MATE1 and MATE2K and Functional Overlap with OCT1 and OCT2.
Journal of medicinal chemistry
Jun 13, 2025
The multidrug and toxin extrusion proteins MATE1 and MATE2K may determine the pharmacokinetics and drug-drug interactions of many drugs. However, their substrate spectrum and synergy with organic cation transporters OCT1 and OCT2 remain incompletely ...
Ecofriendly Extraction of Polyphenols from Leaves Coupled with Response Surface Methodology and Artificial Neural Network-Genetic Algorithm.
Molecules (Basel, Switzerland)
May 28, 2025
This study aimed to optimize a novel deep eutectic solvents (DESs)-assisted extraction process for polyphenols in the leaves of (AGPL) with response surface methodology (RSM) and a genetic algorithm-artificial neural network (GA-ANN). Under the infl...
Classification of Lu'an Gua Pian tea before and after Qingming Festival using HPLC-DAD analysis: a comparison of different data analysis strategies.
Analytical methods : advancing methods and applications
May 15, 2025
Lu'an Gua Pian tea (LAGP) is a traditional Chinese historical tea and one of the top ten famous teas in China. The price of LAGP from the same place of origin varies greatly in the market depending on the harvest time, with the LAGP harvested before ...
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