Thiol compounds can serve as markers for the antioxidant and prognostic status of lymphoma, playing a crucial role in early tumor diagnosis. However, their high polarity and lack of chromophores pose challenges for multivariate analysis. This study a...
BACKGROUND: Mild to moderate depression (MMD), as an early stage of depression, has a high incidence and may progress to severe depression, even leading to suicide. The lack of effective screening and treatment is due to the unknown metabolic changes...
Highly sensitive and selective monitoring of amino metabolites such as glutamine, arginine, tryptophan and related proteins played significant roles in early diagnosis and warning of lymphoma. But those limited abundance and lacked chromophore group ...
Altered gut metabolites are important for the inflammatory progression in children with NAFLD. Fecal and plasma samples were collected from 145 subjects including 53 non-alcoholic fatty liver (NAFL), 39 nonalcoholic steatohepatitis (NASH) and 53 obes...
ETHNOPHARMACOLOGICAL RELEVANCE: Mulberry leaves (Morus alba L.) are used in traditional Chinese medicine to clear the lungs and dispel wind-heat. Despite their common use, chemical reference substance rely solely on rutin, which may not reflect their...
In this study, multivariate analysis (MVA) and machine learning (ML), combined with UHPLC-HRMS, were used to evaluate the freshness of apples for juice production based on the analysis of freshly squeezed apple juice. A total of eight stages of apple...
Tilianin is a commonly used pharmaceutical ingredient with various biological activities such as antioxidant, anti-inflammatory, and anticancer, which is able to exert antitumor effects by inhibiting tumor cell proliferation, inducing apoptosis and i...
The multidrug and toxin extrusion proteins MATE1 and MATE2K may determine the pharmacokinetics and drug-drug interactions of many drugs. However, their substrate spectrum and synergy with organic cation transporters OCT1 and OCT2 remain incompletely ...
Artemisia argyi Folium (AAF) is a widely used functional aromatic medicinal plant with significant health, culinary, and therapeutic value. However, geographical variations in environmental factors notably affect its metabolite production, making com...
International journal of legal medicine
Jun 6, 2025
The sudden death discrimination of acute ischemia heart disease (AIHD) and the determination of the AIHD pathological stage are the difficulties in forensic medicine. More potential biomarkers with high sensitivity and specificity still need to be id...
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