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Identification of contributing genes of Huntington's disease by machine learning.

BMC medical genomics
BACKGROUND: Huntington's disease (HD) is an inherited disorder caused by the polyglutamine (poly-Q) mutations of the HTT gene results in neurodegeneration characterized by chorea, loss of coordination, cognitive decline. However, HD pathogenesis is s...

A random forest based biomarker discovery and power analysis framework for diagnostics research.

BMC medical genomics
BACKGROUND: Biomarker identification is one of the major and important goal of functional genomics and translational medicine studies. Large scale -omics data are increasingly being accumulated and can provide vital means for the identification of bi...

Deep Learning for Voice Gender Identification: Proof-of-concept for Gender-Affirming Voice Care.

The Laryngoscope
OBJECTIVES/HYPOTHESIS: The need for gender-affirming voice care has been increasing in the transgender population in the last decade. Currently, objective treatment outcome measurements are lacking to assess the success of these interventions. This s...

Comparing supervised and unsupervised approaches to emotion categorization in the human brain, body, and subjective experience.

Scientific reports
Machine learning methods provide powerful tools to map physical measurements to scientific categories. But are such methods suitable for discovering the ground truth about psychological categories? We use the science of emotion as a test case to expl...

Identifying cardiomegaly in chest X-rays: a cross-sectional study of evaluation and comparison between different transfer learning methods.

Acta radiologica (Stockholm, Sweden : 1987)
BACKGROUND: Cardiomegaly is a relatively common incidental finding on chest X-rays; if left untreated, it can result in significant complications. Using Artificial Intelligence for diagnosing cardiomegaly could be beneficial, as this pathology may be...

Multi-task convolutional neural network-based design of radio frequency pulse and the accompanying gradients for magnetic resonance imaging.

NMR in biomedicine
Modern MRI systems usually load the predesigned RFs and the accompanying gradients during clinical scans, with minimal adaption to the specific requirements of each scan. Here, we describe a neural network-based method for real-time design of excitat...

A generic deep learning framework to classify thyroid and breast lesions in ultrasound images.

Ultrasonics
Breast and thyroid cancers are the two common cancers to affect women worldwide. Ultrasonography (US) is a commonly used non-invasive imaging modality to detect breast and thyroid cancers, but its clinical diagnostic accuracy for these cancers is con...

Machine learning approaches for sex estimation using cranial measurements.

International journal of legal medicine
The aim of the present study is to apply support vector machines (SVM) and artificial neural network (ANN) as sex classifiers and to generate useful classification models for sex estimation based on cranial measurements. Besides, the performance of t...

Machine learning for psychiatry: getting doctors at the black box?

Molecular psychiatry
Recent developments in the field of machine learning have spurred high hopes for diagnostic support for psychiatric patients based on brain MRI. But while technical advances are undoubtedly remarkable, the current trajectory of mostly proof-of-concep...

A data-driven dimensionality-reduction algorithm for the exploration of patterns in biomedical data.

Nature biomedical engineering
Dimensionality reduction is widely used in the visualization, compression, exploration and classification of data. Yet a generally applicable solution remains unavailable. Here, we report an accurate and broadly applicable data-driven algorithm for d...